NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients

Sunny Malhotra; Melissa Sorosina; Jordi Río; Silvia Peroni; Luciana Midaglia; Luisa M. Villar; José C. Álvarez-Cermeño; Ina Schroeder; Federica Esposito; Ferdinando Clarelli; Uwe K. Zettl; Jeannette Lechner-Scott; Nino Spataro; Arcadi Navarro; Giancarlo Comi; Xavier Montalban; Filippo Martinelli-Boneschi; Manuel Comabella

doi:10.1177/1352458517739137

NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients

Sunny Malhotra, Melissa Sorosina, Jordi Río, Silvia Peroni, Luciana Midaglia, Luisa M. Villar, José C. Álvarez-Cermeño, Ina Schroeder, Federica Esposito, Ferdinando Clarelli, Uwe K. Zettl, Jeannette Lechner-Scott, Nino Spataro, Arcadi Navarro, Giancarlo Comi, Xavier Montalban, Filippo Martinelli-Boneschi, Manuel Comabella

Departament de Medicina

Producció científica: Contribució a revista › Article › Recerca

9 Cites (Scopus)

Resum

© The Author(s), 2017. We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNβ and NLRP3 polymorphisms. These findings do not support a role of polymorphisms located in the NLRP3 gene and the response to IFNβ in MS patients.

Idioma original	Anglès
Pàgines (de-a)	1507-1510
Revista	Multiple Sclerosis Journal
Volum	24
DOIs	https://doi.org/10.1177/1352458517739137
Estat de la publicació	Publicada - 1 d’oct. 2018

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10.1177/1352458517739137

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Malhotra, S., Sorosina, M., Río, J., Peroni, S., Midaglia, L., Villar, L. M., Álvarez-Cermeño, J. C., Schroeder, I., Esposito, F., Clarelli, F., Zettl, U. K., Lechner-Scott, J., Spataro, N., Navarro, A., Comi, G., Montalban, X., Martinelli-Boneschi, F., & Comabella, M. (2018). NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients. Multiple Sclerosis Journal, 24, 1507-1510. https://doi.org/10.1177/1352458517739137

@article{d19fbb6be44349ca823b586ed65a7c67,

title = "NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients",

abstract = "{\textcopyright} The Author(s), 2017. We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNβ and NLRP3 polymorphisms. These findings do not support a role of polymorphisms located in the NLRP3 gene and the response to IFNβ in MS patients.",

keywords = "inflammasome, interferon-beta, Multiple sclerosis, polymorphisms",

author = "Sunny Malhotra and Melissa Sorosina and Jordi R{\'i}o and Silvia Peroni and Luciana Midaglia and Villar, {Luisa M.} and {\'A}lvarez-Cerme{\~n}o, {Jos{\'e} C.} and Ina Schroeder and Federica Esposito and Ferdinando Clarelli and Zettl, {Uwe K.} and Jeannette Lechner-Scott and Nino Spataro and Arcadi Navarro and Giancarlo Comi and Xavier Montalban and Filippo Martinelli-Boneschi and Manuel Comabella",

year = "2018",

month = oct,

day = "1",

doi = "10.1177/1352458517739137",

language = "English",

volume = "24",

pages = "1507--1510",

journal = "Multiple Sclerosis Journal",

issn = "1352-4585",

publisher = "SAGE Publications Ltd",

}

Malhotra, S, Sorosina, M, Río, J, Peroni, S, Midaglia, L, Villar, LM, Álvarez-Cermeño, JC, Schroeder, I, Esposito, F, Clarelli, F, Zettl, UK, Lechner-Scott, J, Spataro, N, Navarro, A, Comi, G, Montalban, X, Martinelli-Boneschi, F & Comabella, M 2018, 'NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients', Multiple Sclerosis Journal, vol. 24, pàg. 1507-1510. https://doi.org/10.1177/1352458517739137

TY - JOUR

T1 - NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients

AU - Malhotra, Sunny

AU - Sorosina, Melissa

AU - Río, Jordi

AU - Peroni, Silvia

AU - Midaglia, Luciana

AU - Villar, Luisa M.

AU - Álvarez-Cermeño, José C.

AU - Schroeder, Ina

AU - Esposito, Federica

AU - Clarelli, Ferdinando

AU - Zettl, Uwe K.

AU - Lechner-Scott, Jeannette

AU - Spataro, Nino

AU - Navarro, Arcadi

AU - Comi, Giancarlo

AU - Montalban, Xavier

AU - Martinelli-Boneschi, Filippo

AU - Comabella, Manuel

PY - 2018/10/1

Y1 - 2018/10/1

N2 - © The Author(s), 2017. We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNβ and NLRP3 polymorphisms. These findings do not support a role of polymorphisms located in the NLRP3 gene and the response to IFNβ in MS patients.

AB - © The Author(s), 2017. We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNβ and NLRP3 polymorphisms. These findings do not support a role of polymorphisms located in the NLRP3 gene and the response to IFNβ in MS patients.

KW - inflammasome

KW - interferon-beta

KW - Multiple sclerosis

KW - polymorphisms

U2 - 10.1177/1352458517739137

DO - 10.1177/1352458517739137

M3 - Article

C2 - 29117789

SN - 1352-4585

VL - 24

SP - 1507

EP - 1510

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

ER -

NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients

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