Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys

María Rebeca Toledo-Cárdenas; Francisco Ros-Bernal; María Trinidad Herrero; Paola Heman; Carlos Barcia; Aurora Gómez; José Enrique Yuste; Emiliano Fernandez-Villalba; Vicente de Pablos; Carmen M. Ros

Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys

María Rebeca Toledo-Cárdenas, Francisco Ros-Bernal, María Trinidad Herrero, Paola Heman, Carlos Barcia, Aurora Gómez, José Enrique Yuste, Emiliano Fernandez-Villalba, Vicente de Pablos, Carmen M. Ros

Institut de Neurociències (INc)

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In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of chronic parkinsonian macaques, characterized by the expression of c-Fos, which correlated with dopaminergic degeneration. These results are compatible with the results observed in fMRI in Parkinson's disease patients, and may contribute to the understanding of additional alterations in the brain circuitry in Parkinsonism.

Idioma original	Anglès
Pàgines (de-a)	89-94
Nombre de pàgines	6
Revista	Histology and Histopathology
Volum	27
Número	1
Estat de la publicació	Publicada - de gen. 2012

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keywords = "Cerebellum, Parkinson's disease, Purkinje cells, c-Fos, MPTP",

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language = "English",

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T1 - Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys

AU - Toledo-Cárdenas, María Rebeca

AU - Ros-Bernal, Francisco

AU - Herrero, María Trinidad

AU - Heman, Paola

AU - Barcia, Carlos

AU - Gómez, Aurora

AU - Yuste, José Enrique

AU - Fernandez-Villalba, Emiliano

AU - de Pablos, Vicente

AU - Ros, Carmen M.

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Y1 - 2012/1

N2 - In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of chronic parkinsonian macaques, characterized by the expression of c-Fos, which correlated with dopaminergic degeneration. These results are compatible with the results observed in fMRI in Parkinson's disease patients, and may contribute to the understanding of additional alterations in the brain circuitry in Parkinsonism.

AB - In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of chronic parkinsonian macaques, characterized by the expression of c-Fos, which correlated with dopaminergic degeneration. These results are compatible with the results observed in fMRI in Parkinson's disease patients, and may contribute to the understanding of additional alterations in the brain circuitry in Parkinsonism.

KW - Cerebellum

KW - Parkinson's disease

KW - Purkinje cells

KW - c-Fos

KW - MPTP

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Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys

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