New molecular medicine-based scar management strategies

Anna I. Arno; Gerd G. Gauglitz; Juan P. Barret; Marc G. Jeschke

doi:10.1016/j.burns.2013.11.010

New molecular medicine-based scar management strategies

Anna I. Arno, Gerd G. Gauglitz, Juan P. Barret, Marc G. Jeschke^*

^*Autor corresponent d’aquest treball

Departament de Cirurgia

Producció científica: Contribució a revista › Article de revisió › Recerca › Avaluat per experts

42 Cites (Scopus)

Resum

Keloids and hypertrophic scars are prevalent disabling conditions with still suboptimal treatments. Basic science and molecular-based medicine research have contributed to unravel new bench-to-bedside scar therapies and to dissect the complex signalling pathways involved. Peptides such as the transforming growth factor beta (TGF-β) superfamily, with Smads, Ski, SnoN, Fussels, endoglin, DS-Sily, Cav-1p, AZX100, thymosin-β4 and other related molecules may emerge as targets to prevent and treat keloids and hypertrophic scars. The aim of this review is to describe the basic complexity of these new molecular scar management strategies and point out new fibrosis research lines.

Idioma original	Anglès nord-americà
Pàgines (de-a)	539-551
Nombre de pàgines	13
Revista	Burns
Volum	40
Número	4
DOIs	https://doi.org/10.1016/j.burns.2013.11.010
Estat de la publicació	Publicada - de juny 2014

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10.1016/j.burns.2013.11.010

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https://www.scopus.com/pages/publications/84899654209

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@article{a28a18dcec66454dab80c6e488c7e4ac,

title = "New molecular medicine-based scar management strategies",

abstract = "Keloids and hypertrophic scars are prevalent disabling conditions with still suboptimal treatments. Basic science and molecular-based medicine research have contributed to unravel new bench-to-bedside scar therapies and to dissect the complex signalling pathways involved. Peptides such as the transforming growth factor beta (TGF-β) superfamily, with Smads, Ski, SnoN, Fussels, endoglin, DS-Sily, Cav-1p, AZX100, thymosin-β4 and other related molecules may emerge as targets to prevent and treat keloids and hypertrophic scars. The aim of this review is to describe the basic complexity of these new molecular scar management strategies and point out new fibrosis research lines.",

keywords = "Endoglin, FAP-alpha/DPPIV, Fussels, Keloid, Rapamycin, Review, Scar, Ski, SnoN, TGF-β",

author = "Arno, \{Anna I.\} and Gauglitz, \{Gerd G.\} and Barret, \{Juan P.\} and Jeschke, \{Marc G.\}",

year = "2014",

month = jun,

doi = "10.1016/j.burns.2013.11.010",

language = "Ingl{\'e}s estadounidense",

volume = "40",

pages = "539--551",

journal = "Burns",

issn = "0305-4179",

publisher = "Elsevier Limited",

number = "4",

}

TY - JOUR

T1 - New molecular medicine-based scar management strategies

AU - Arno, Anna I.

AU - Gauglitz, Gerd G.

AU - Barret, Juan P.

AU - Jeschke, Marc G.

PY - 2014/6

Y1 - 2014/6

N2 - Keloids and hypertrophic scars are prevalent disabling conditions with still suboptimal treatments. Basic science and molecular-based medicine research have contributed to unravel new bench-to-bedside scar therapies and to dissect the complex signalling pathways involved. Peptides such as the transforming growth factor beta (TGF-β) superfamily, with Smads, Ski, SnoN, Fussels, endoglin, DS-Sily, Cav-1p, AZX100, thymosin-β4 and other related molecules may emerge as targets to prevent and treat keloids and hypertrophic scars. The aim of this review is to describe the basic complexity of these new molecular scar management strategies and point out new fibrosis research lines.

AB - Keloids and hypertrophic scars are prevalent disabling conditions with still suboptimal treatments. Basic science and molecular-based medicine research have contributed to unravel new bench-to-bedside scar therapies and to dissect the complex signalling pathways involved. Peptides such as the transforming growth factor beta (TGF-β) superfamily, with Smads, Ski, SnoN, Fussels, endoglin, DS-Sily, Cav-1p, AZX100, thymosin-β4 and other related molecules may emerge as targets to prevent and treat keloids and hypertrophic scars. The aim of this review is to describe the basic complexity of these new molecular scar management strategies and point out new fibrosis research lines.

KW - Endoglin

KW - FAP-alpha/DPPIV

KW - Fussels

KW - Keloid

KW - Rapamycin

KW - Review

KW - Scar

KW - Ski

KW - SnoN

KW - TGF-β

UR - https://www.scopus.com/pages/publications/84899654209

U2 - 10.1016/j.burns.2013.11.010

DO - 10.1016/j.burns.2013.11.010

M3 - Artículo de revisión

C2 - 24438742

AN - SCOPUS:84899654209

SN - 0305-4179

VL - 40

SP - 539

EP - 551

JO - Burns

JF - Burns

IS - 4

ER -

New molecular medicine-based scar management strategies

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