TY - JOUR
T1 - New iron(II) cyclopentadienyl derivative complexes: Synthesis and antitumor activity against human leukemia cancer cells
AU - Valente, Andreia
AU - Santos, Ana Margarida
AU - Côrte-Real, Leonor
AU - Robalo, M. Paula
AU - Moreno, Virtudes
AU - Font-Bardia, Mercè
AU - Calvet, Teresa
AU - Lorenzo, Julia
AU - Garcia, M. Helena
PY - 2014/4/15
Y1 - 2014/4/15
N2 - A new family of "FeII(η5-C5H 5)" half sandwich compounds bearing a N-heteroaromatic ligand coordinated to the iron center by a nitrile functional group has been synthesized and fully characterized by NMR and UV-Vis spectroscopy. X-ray analysis of single crystal was achieved for complexes 1 and 3, which crystallized in the monoclinic P21/c and monoclinic P21/n space groups, respectively. Studies of interaction of these five new complexes with plasmid pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC50 values revealed excellent antiproliferative activity compared to cisplatin. © 2014 Elsevier B.V. All rights reserved.
AB - A new family of "FeII(η5-C5H 5)" half sandwich compounds bearing a N-heteroaromatic ligand coordinated to the iron center by a nitrile functional group has been synthesized and fully characterized by NMR and UV-Vis spectroscopy. X-ray analysis of single crystal was achieved for complexes 1 and 3, which crystallized in the monoclinic P21/c and monoclinic P21/n space groups, respectively. Studies of interaction of these five new complexes with plasmid pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC50 values revealed excellent antiproliferative activity compared to cisplatin. © 2014 Elsevier B.V. All rights reserved.
KW - Apoptosis
KW - Atomic force microscopy (AFM)
KW - Cyclopentadienyl
KW - Iron(II)
KW - Leukemia cancer cells
U2 - 10.1016/j.jorganchem.2014.01.027
DO - 10.1016/j.jorganchem.2014.01.027
M3 - Article
SN - 0022-328X
VL - 756
SP - 52
EP - 60
JO - Journal of Organometallic Chemistry
JF - Journal of Organometallic Chemistry
ER -
