New chromosomal alterations in a series of 23 splenic marginal zone lymphoma patients revealed by Spectral Karyotyping (SKY)

Cristina Baró; Marta Salido; Blanca Espinet; Laura Astier; Alicia Domingo; Isabel Granada; Fuensanta Millà; Ana Carrió; Dolors Costa; Elisa Luño; Jesús Ma Hernández; Elias Campo; Lourdes Florensa; Ana Ferrer; Antonio Salar; Beatriz Bellosillo; Carles Besses; Sergi Serrano; Francesc Solé

doi:10.1016/j.leukres.2007.09.012

New chromosomal alterations in a series of 23 splenic marginal zone lymphoma patients revealed by Spectral Karyotyping (SKY)

Cristina Baró, Marta Salido, Blanca Espinet, Laura Astier, Alicia Domingo, Isabel Granada, Fuensanta Millà, Ana Carrió, Dolors Costa, Elisa Luño, Jesús Ma Hernández, Elias Campo, Lourdes Florensa, Ana Ferrer, Antonio Salar, Beatriz Bellosillo, Carles Besses, Sergi Serrano, Francesc Solé

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Resum

Splenic marginal zone lymphoma (SMZL) is a B-cell lymphoproliferative disorder with characteristic clinical, immunophenotypic, cytological and histological features. Some karyotypic abnormalities have been related to this disorder and most of them are usually complex and difficult to define. The aim of present study was to characterize new chromosomal aberrations involved in this disease. We performed conventional banding cytogenetics and Spectral Karyotyping (SKY) technique in 23 patients diagnosed with SMZL having a complex karyotype among a series of 160 SMZL cases. Del(7)(q22-q32) and trisomy 3/3q were the most common chromosomal aberrations. In addition, new translocations involving chromosomes 3, 6, 8, 9, 12 and 14q32 region were detected. © 2007 Elsevier Ltd. All rights reserved.

Idioma original	Anglès
Pàgines (de-a)	727-736
Revista	Leukemia Research
Volum	32
Número	5
DOIs	https://doi.org/10.1016/j.leukres.2007.09.012
Estat de la publicació	Publicada - 1 de gen. 2008

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10.1016/j.leukres.2007.09.012

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Baró, C., Salido, M., Espinet, B., Astier, L., Domingo, A., Granada, I., Millà, F., Carrió, A., Costa, D., Luño, E., Hernández, J. M., Campo, E., Florensa, L., Ferrer, A., Salar, A., Bellosillo, B., Besses, C., Serrano, S., & Solé, F. (2008). New chromosomal alterations in a series of 23 splenic marginal zone lymphoma patients revealed by Spectral Karyotyping (SKY). Leukemia Research, 32(5), 727-736. https://doi.org/10.1016/j.leukres.2007.09.012

@article{00467c8955164947a23b9f8a7dbf4c6e,

title = "New chromosomal alterations in a series of 23 splenic marginal zone lymphoma patients revealed by Spectral Karyotyping (SKY)",

abstract = "Splenic marginal zone lymphoma (SMZL) is a B-cell lymphoproliferative disorder with characteristic clinical, immunophenotypic, cytological and histological features. Some karyotypic abnormalities have been related to this disorder and most of them are usually complex and difficult to define. The aim of present study was to characterize new chromosomal aberrations involved in this disease. We performed conventional banding cytogenetics and Spectral Karyotyping (SKY) technique in 23 patients diagnosed with SMZL having a complex karyotype among a series of 160 SMZL cases. Del(7)(q22-q32) and trisomy 3/3q were the most common chromosomal aberrations. In addition, new translocations involving chromosomes 3, 6, 8, 9, 12 and 14q32 region were detected. {\textcopyright} 2007 Elsevier Ltd. All rights reserved.",

keywords = "Cytogenetics, FISH, SKY, Splenic marginal zone lymphoma",

author = "Cristina Bar{\'o} and Marta Salido and Blanca Espinet and Laura Astier and Alicia Domingo and Isabel Granada and Fuensanta Mill{\`a} and Ana Carri{\'o} and Dolors Costa and Elisa Lu{\~n}o and Hern{\'a}ndez, {Jes{\'u}s Ma} and Elias Campo and Lourdes Florensa and Ana Ferrer and Antonio Salar and Beatriz Bellosillo and Carles Besses and Sergi Serrano and Francesc Sol{\'e}",

year = "2008",

month = jan,

day = "1",

doi = "10.1016/j.leukres.2007.09.012",

language = "English",

volume = "32",

pages = "727--736",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Limited",

number = "5",

}

Baró, C, Salido, M, Espinet, B, Astier, L, Domingo, A, Granada, I, Millà, F, Carrió, A, Costa, D, Luño, E, Hernández, JM, Campo, E, Florensa, L, Ferrer, A, Salar, A, Bellosillo, B, Besses, C, Serrano, S & Solé, F 2008, 'New chromosomal alterations in a series of 23 splenic marginal zone lymphoma patients revealed by Spectral Karyotyping (SKY)', Leukemia Research, vol. 32, núm. 5, pàg. 727-736. https://doi.org/10.1016/j.leukres.2007.09.012

TY - JOUR

T1 - New chromosomal alterations in a series of 23 splenic marginal zone lymphoma patients revealed by Spectral Karyotyping (SKY)

AU - Baró, Cristina

AU - Salido, Marta

AU - Espinet, Blanca

AU - Astier, Laura

AU - Domingo, Alicia

AU - Granada, Isabel

AU - Millà, Fuensanta

AU - Carrió, Ana

AU - Costa, Dolors

AU - Luño, Elisa

AU - Hernández, Jesús Ma

AU - Campo, Elias

AU - Florensa, Lourdes

AU - Ferrer, Ana

AU - Salar, Antonio

AU - Bellosillo, Beatriz

AU - Besses, Carles

AU - Serrano, Sergi

AU - Solé, Francesc

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Splenic marginal zone lymphoma (SMZL) is a B-cell lymphoproliferative disorder with characteristic clinical, immunophenotypic, cytological and histological features. Some karyotypic abnormalities have been related to this disorder and most of them are usually complex and difficult to define. The aim of present study was to characterize new chromosomal aberrations involved in this disease. We performed conventional banding cytogenetics and Spectral Karyotyping (SKY) technique in 23 patients diagnosed with SMZL having a complex karyotype among a series of 160 SMZL cases. Del(7)(q22-q32) and trisomy 3/3q were the most common chromosomal aberrations. In addition, new translocations involving chromosomes 3, 6, 8, 9, 12 and 14q32 region were detected. © 2007 Elsevier Ltd. All rights reserved.

AB - Splenic marginal zone lymphoma (SMZL) is a B-cell lymphoproliferative disorder with characteristic clinical, immunophenotypic, cytological and histological features. Some karyotypic abnormalities have been related to this disorder and most of them are usually complex and difficult to define. The aim of present study was to characterize new chromosomal aberrations involved in this disease. We performed conventional banding cytogenetics and Spectral Karyotyping (SKY) technique in 23 patients diagnosed with SMZL having a complex karyotype among a series of 160 SMZL cases. Del(7)(q22-q32) and trisomy 3/3q were the most common chromosomal aberrations. In addition, new translocations involving chromosomes 3, 6, 8, 9, 12 and 14q32 region were detected. © 2007 Elsevier Ltd. All rights reserved.

KW - Cytogenetics

KW - FISH

KW - SKY

KW - Splenic marginal zone lymphoma

U2 - 10.1016/j.leukres.2007.09.012

DO - 10.1016/j.leukres.2007.09.012

M3 - Article

SN - 0145-2126

VL - 32

SP - 727

EP - 736

JO - Leukemia Research

JF - Leukemia Research

IS - 5

ER -

New chromosomal alterations in a series of 23 splenic marginal zone lymphoma patients revealed by Spectral Karyotyping (SKY)

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