TY - JOUR
T1 - New 2-[(5-methoxy-1-methylindolyl)]-alkylamine derivatives: The effect of branching and elongation of the side chain on MAO inhibition
AU - Morón, J. A.
AU - Perez, V.
AU - Marco, J. L.
AU - Fernandez-Alvarez, E.
AU - Unzeta, M.
PY - 1998/1/1
Y1 - 1998/1/1
N2 - A novel series of previously synthesised 2-[(5-methoxy-1-methylindolyl)]alkylamine derivatives were irreversible and time-dependent mechanism-based inhibitors of MAO. The effect of branching and elongation of the side chain was evaluated on the inhibitory potency towards MAO-A and MAO-B activities. The K(I) of the reversible step and the k(inact) of the irreversible one were determined in each case. The results obtained lead to the conclusion that neither the elongation nor the branching of the side chain improve the potency of the compounds as MAO inhibitors.
AB - A novel series of previously synthesised 2-[(5-methoxy-1-methylindolyl)]alkylamine derivatives were irreversible and time-dependent mechanism-based inhibitors of MAO. The effect of branching and elongation of the side chain was evaluated on the inhibitory potency towards MAO-A and MAO-B activities. The K(I) of the reversible step and the k(inact) of the irreversible one were determined in each case. The results obtained lead to the conclusion that neither the elongation nor the branching of the side chain improve the potency of the compounds as MAO inhibitors.
KW - Indolalkylamine derivatives
KW - Inhibition
KW - Kinetics
KW - Monoamine oxidase
UR - https://www.scopus.com/pages/publications/0031694791
U2 - 10.3109/14756369809021473
DO - 10.3109/14756369809021473
M3 - Article
SN - 8755-5093
VL - 13
SP - 237
EP - 251
JO - Journal of Enzyme Inhibition
JF - Journal of Enzyme Inhibition
IS - 4
ER -