TY - JOUR
T1 - Neural correlates of impaired emotional discrimination in borderline personality disorder: An fMRI study
AU - Guitart-Masip, Marc
AU - Pascual, Juan Carlos
AU - Carmona, Susanna
AU - Hoekzema, Elseline
AU - Bergé, Daniel
AU - Pérez, Víctor
AU - Soler, Joaquim
AU - Soliva, Joan Carles
AU - Rovira, Mariana
AU - Bulbena, Antoni
AU - Vilarroya, Oscar
PY - 2009/11/13
Y1 - 2009/11/13
N2 - A common approach to study neuronal aspects of emotional reactivity of borderline personality disorder (BPD) is to study the brain response to emotional faces with functional magnetic resonance imaging (fMRI). 10 BPD patients and 10 matched controls were submitted to an emotional discrimination task in which subjects had to identify an emotional face from a neutral face while fMRI data was acquired. BPD patients made more mistakes than controls in the discrimination task when negative faces were involved. The emotional discrimination task activated brain areas that are known to participate in processing of emotional faces (fusiform gyrus, insula and amygdala) regardless of the psychiatric condition. Additionally, BPD showed higher activation than controls in the middle and inferior temporal cortical areas, brain areas that participate in the processing of face features that carry emotional value. Furthermore, activity at this site correlated with impulsivity score in the Zuckerman-Kuhlman Personality Questionnaire. Our findings may be related to cognitive impairment that may be characteristic of the disorder. © 2009 Elsevier Inc. All rights reserved.
AB - A common approach to study neuronal aspects of emotional reactivity of borderline personality disorder (BPD) is to study the brain response to emotional faces with functional magnetic resonance imaging (fMRI). 10 BPD patients and 10 matched controls were submitted to an emotional discrimination task in which subjects had to identify an emotional face from a neutral face while fMRI data was acquired. BPD patients made more mistakes than controls in the discrimination task when negative faces were involved. The emotional discrimination task activated brain areas that are known to participate in processing of emotional faces (fusiform gyrus, insula and amygdala) regardless of the psychiatric condition. Additionally, BPD showed higher activation than controls in the middle and inferior temporal cortical areas, brain areas that participate in the processing of face features that carry emotional value. Furthermore, activity at this site correlated with impulsivity score in the Zuckerman-Kuhlman Personality Questionnaire. Our findings may be related to cognitive impairment that may be characteristic of the disorder. © 2009 Elsevier Inc. All rights reserved.
KW - Borderline personality disorder
KW - Emotion recognition
KW - Emotional instability
KW - fMRI
U2 - 10.1016/j.pnpbp.2009.08.022
DO - 10.1016/j.pnpbp.2009.08.022
M3 - Article
SN - 0278-5846
VL - 33
SP - 1537
EP - 1545
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
IS - 8
ER -