TY - JOUR
T1 - Native valve endocarditis due to Candida glabrata treated without valvular replacement
T2 - a potential role for caspofungin in the induction and maintenance treatment.
AU - Jiménez-Expósito, M. J.
AU - Torres, G.
AU - Baraldés, A.
AU - Benito, N.
AU - Marco, F.
AU - Paré, J. C.
AU - Moreno, A.
AU - Claramonte, X.
AU - Mestres, C. A.
AU - Almela, M.
AU - García de la María, C.
AU - Pérez, N.
AU - Schell, W. A.
AU - Corey, G. R.
AU - Perfect, J.
AU - Jiménez de Anta, M. T.
AU - Gatell, J. M.
AU - Miró, J. M.
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2004/10/1
Y1 - 2004/10/1
N2 - Conventional antifungal therapy for fungal endocarditis has been associated with a poor cure rate. Therefore, combined medical and surgical therapy has been recommended. However, new potent antifungal agents, such as echinocandins, could increase the medical options and, in some cases, avoid the need for surgery. We report a case of Candida endocarditis treated successfully without valve replacement with intravenous liposomal amphotericin B (total dose, 4 g) and intravenous caspofungin (a 100-mg loading dose followed by 50 mg per day for 8 weeks) as induction therapy and intravenous caspofungin (100 mg 3 times per week for 12 weeks) as maintenance therapy.
AB - Conventional antifungal therapy for fungal endocarditis has been associated with a poor cure rate. Therefore, combined medical and surgical therapy has been recommended. However, new potent antifungal agents, such as echinocandins, could increase the medical options and, in some cases, avoid the need for surgery. We report a case of Candida endocarditis treated successfully without valve replacement with intravenous liposomal amphotericin B (total dose, 4 g) and intravenous caspofungin (a 100-mg loading dose followed by 50 mg per day for 8 weeks) as induction therapy and intravenous caspofungin (100 mg 3 times per week for 12 weeks) as maintenance therapy.
UR - https://www.scopus.com/pages/publications/14344249357
U2 - 10.1086/424018
DO - 10.1086/424018
M3 - Article
C2 - 15472836
AN - SCOPUS:14344249357
SN - 1058-4838
VL - 39
SP - e70-73
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 7
ER -
