Nanoparticle-induced catalysis for electrochemical DNA biosensors

In this chapter, the use of nanoparticles (NPs) in catalytic electrochemical analysis of DNA as a new detection strategy reported in recent years is revised. The topics covered here include labeling with nanoparticles and their subsequent signal enhancement employed for DNA hybridization detection. Direct sensing of nanoparticle labels as well as indirect detection routes through electrochemical sensing of label-catalyzed reactions have been reported. Nanofabrication of platforms used for the detection of DNA through electrochemical signal amplification has also been revised. Some recent examples of interesting nanoparticleinduced catalytic methodologies applied for protein detection using electrochemical biosensors are also given, because of their potential interest in future applications in DNA detection. © 2012 Pan Stanford Publishing Pte. Ltd. All rights reserved.