TY - JOUR
T1 - MYC protein expression is associated with poor prognosis in primary diffuse large B-cell lymphoma of the central nervous system
AU - Tapia, Gustavo
AU - Baptista, Maria Joao
AU - Muñoz-Marmol, Ana Maria
AU - Gaafar, Ayman
AU - Puente-Pomposo, Maria
AU - Garcia, Olga
AU - Marginet-Flinch, Ruth
AU - Sanz, Carolina
AU - Navarro, Jose Tomas
AU - Sancho, Juan Manuel
AU - Ribera, Josep Maria
AU - Ariza, Aurelio
AU - Mate, Jose Luis
PY - 2015/1/1
Y1 - 2015/1/1
N2 - © 2015 APMIS. Published by John Wiley & Sons Ltd. MYC and BCL2 gene translocations and protein expression have recently demonstrated to be of prognostic significance in systemic diffuse large B-cell lymphoma (DLBCL). However, their role in primary central nervous system DLBCL (CNS-DLBCL) prognosis has been scarcely analyzed. We studied the immunophenotype, the status of the MYC, BCL2, and BCL6 genes and the clinical features of a series of 42 CNS-DLBCL and evaluated their prognostic significance. We found high MYC protein expression in 43% of cases, and this was associated with lower overall survival (OS). Cases with concurrent expression of MYC and BCL2 showed a lower OS, although the difference did not reach statistical significance. Translocations involving the MYC or BCL2 genes were not detected. The BCL6 gene was frequently translocated, but was unrelated to survival. We conclude that MYC protein expression detected by immunohistochemistry identifies a CNS-DLBCL subset with worse prognosis and may contribute to a more accurate risk stratification of CNS-DLBCL patients.
AB - © 2015 APMIS. Published by John Wiley & Sons Ltd. MYC and BCL2 gene translocations and protein expression have recently demonstrated to be of prognostic significance in systemic diffuse large B-cell lymphoma (DLBCL). However, their role in primary central nervous system DLBCL (CNS-DLBCL) prognosis has been scarcely analyzed. We studied the immunophenotype, the status of the MYC, BCL2, and BCL6 genes and the clinical features of a series of 42 CNS-DLBCL and evaluated their prognostic significance. We found high MYC protein expression in 43% of cases, and this was associated with lower overall survival (OS). Cases with concurrent expression of MYC and BCL2 showed a lower OS, although the difference did not reach statistical significance. Translocations involving the MYC or BCL2 genes were not detected. The BCL6 gene was frequently translocated, but was unrelated to survival. We conclude that MYC protein expression detected by immunohistochemistry identifies a CNS-DLBCL subset with worse prognosis and may contribute to a more accurate risk stratification of CNS-DLBCL patients.
KW - BCL2
KW - Immunohistochemistry
KW - MYC
KW - Primary CNS lymphoma
KW - Prognosis
U2 - 10.1111/apm.12390
DO - 10.1111/apm.12390
M3 - Article
SN - 0903-4641
VL - 123
SP - 596
EP - 603
JO - APMIS
JF - APMIS
IS - 7
ER -