TY - JOUR
T1 - Multiple adverse drug reactions and genetic polymorphism testing
AU - Arellano, Ana Lucía
AU - Martin-Subero, Marta
AU - Monerris, Mar
AU - Llerena, Adrián
AU - Farré, Magí
AU - Montané, Eva
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. Rationale: Defects in drug metabolic pathways could explain why some patients have a history of multiple adverse drug reactions (ADR); therefore we aimed to analyze genetic polymorphisms in a patient with multiple ADR related to drugs with a common hepatic metabolic pathway through CYP2D6. Patient concerns: We report a patient with psychosis and hypertension related to amitriptyline, tramadol, and duloxetine within a 2-year period. Interventions and Outcomes: A pharmacogenetic test was performed to assess the causative role of the CYP2D6 enzyme, but did not demonstrate a metabolic deficiency. Lessons: Although negative results in the reported case; typing for cytochrome P450 isoenzyme polymorphisms could be a useful diagnostic tool in some patients with a history of multiple ADR.
AB - Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. Rationale: Defects in drug metabolic pathways could explain why some patients have a history of multiple adverse drug reactions (ADR); therefore we aimed to analyze genetic polymorphisms in a patient with multiple ADR related to drugs with a common hepatic metabolic pathway through CYP2D6. Patient concerns: We report a patient with psychosis and hypertension related to amitriptyline, tramadol, and duloxetine within a 2-year period. Interventions and Outcomes: A pharmacogenetic test was performed to assess the causative role of the CYP2D6 enzyme, but did not demonstrate a metabolic deficiency. Lessons: Although negative results in the reported case; typing for cytochrome P450 isoenzyme polymorphisms could be a useful diagnostic tool in some patients with a history of multiple ADR.
KW - CYP2D6
KW - adverse drug reactions
KW - drug metabolism
KW - genetic polymorphism
KW - multiple drug intolerance syndrome
U2 - 10.1097/MD.0000000000008505
DO - 10.1097/MD.0000000000008505
M3 - Article
SN - 0025-7974
VL - 96
JO - Medicine (United States)
JF - Medicine (United States)
IS - 45
M1 - e8505
ER -