Motility patterns and distribution of interstitial cells of Cajal and nitrergic neurons in the proximal, mid- and distal-colon of the rat

E. Albertí, H. B. Mikkelsen, J. O. Larsen, M. Jiménez

Producció científica: Contribució a revistaArticleRecercaAvaluat per experts

62 Cites (Scopus)

Resum

The aim of this work was to study the patterns of spontaneous motility in the circular and longitudinal muscle strips and to characterize the distribution of c-kit positive interstitial cells of Cajal (ICCs) and nitrergic neurons (nNOS) in the proximal, mid- and distal-colon of Sprague-Dawley rats. We described two types of spontaneous contractions: high frequency (HF) and low frequency (LF) contractions, which were recorded in the presence of tetrodotoxin, suggesting a non-neurogenic origin. Regional differences were found in the motility patterns depending on the muscle layer and on the part of the colon studied. Muscle strips without submuscular plexus (SMP) showed only LF contractions. The density of ICCs was of the same magnitude along the extent of the colon: about 90-120 cells mm-2 at Auerbach's plexus (AP) and 50-60 cells mm-2 at the SMP. nNOS positive cells were found at the level of the AP and the major density was found in the mid-colon. Electrical field stimulation abolished LF but did not affect HF contractions. Our results indicate that HF contractions are due to the ICC network found associated with the submuscular plexus (ICC-SMP). The origin of LF contractions is still unknown.
Idioma originalAnglès
Pàgines (de-a)133-147
RevistaNeurogastroenterology and Motility
Volum17
DOIs
Estat de la publicacióPublicada - 1 de febr. 2005

Fingerprint

Navegar pels temes de recerca de 'Motility patterns and distribution of interstitial cells of Cajal and nitrergic neurons in the proximal, mid- and distal-colon of the rat'. Junts formen un fingerprint únic.

Com citar-ho