Molecular characterization and clinical impact of human bocavirus at a tertiary hospital in Barcelona (Catalonia, Spain) during the 2014–2017 seasons

Maria Piñana, Jorgina Vila, Cristina Andrés, Jordi Saura, Alejandra González-Sánchez, Anna Creus-Costa, Narcís Saubi, Juliana Esperalba, Ariadna Rando, Manuel Jesús Iglesias-Cabezas, Josep Quer, Antoni Soriano-Arandes, Pere Soler-Palacín, Tomàs Pumarola*, Andrés Antón*

*Autor corresponent d’aquest treball

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Resum

Purpose: The aim was to describe the prevalence, molecular epidemiology and clinical manifestations of human bocavirus (HBoV) in patients attended at a tertiary hospital in Barcelona, Spain. Methods: From October 2014 to May 2017, respiratory specimens from paediatric patients were collected for respiratory viruses’ laboratory-confirmation. Phylogenetic analyses from partial VP1 sequences were performed from all HBoV laboratory-confirmed specimens. Clinical features were retrospectively studied. Results: 178/10271 cases were HBoV laboratory-confirmed. The median age was 1.53 (IQR 1.0–2.3). Co-detection was highly reported (136; 76%). All viruses belonged into HBoV1 genotype but one into HBoV2. Non-reported mutations were observed and two sites were suggestive to be under negative selection. 61% (109/178) cases had lower RTI (LRTI), of whom 84 had co-detections (77%) and 76 had comorbidities (70%). LRTI was the cause of hospitalization in 85 out of 109 cases (78%), and no differences were found regarding severity factors during hospitalization between co- and single-detections, except for median length of respiratory support, which was longer in cases with co-detections. Conclusions: Close monitoring of predominant HBoV1 showed a high similarity between viruses. The presence of comorbidities might explain the high prevalence of LRTI. Symptomatology in HBoV single-detected cases suggest that HBoV is a true pathogen.

Idioma originalAnglès
Pàgines (de-a)935-943
Nombre de pàgines9
RevistaInfection
Volum51
Número4
DOIs
Estat de la publicacióPublicada - 19 de nov. 2022

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