TY - JOUR
T1 - Molecular analysis of ancient caries
AU - Simón, Marc
AU - Montiel, Rafael
AU - Smerling, Andrea
AU - Solórzano, Eduvigis
AU - Díaz, Nancy
AU - Álvarez-Sandoval, Brenda A.
AU - Jiménez-Marín, Andrea R.
AU - Malgosa, Assumpció
PY - 2014/7/23
Y1 - 2014/7/23
N2 - An 84 base pair sequence of the Streptococcus mutansvirulence factor, known as dextranase, has been obtained from 10 individuals from the Bronze Age to the Modern Era in Europe and from before and after the colonization in America. Modern samples show four polymorphic sites that have not been found in the ancient samples studied so far. The nucleotide and haplotype diversity of this region have increased over time, which could be reflecting the footprint of a population expansion. While this segment has apparently evolved according to neutral evolution, we have been able to detect one site that is under positive selection pressure both in present and past populations. This study is a first step to study the evolution of this microorganism, analysed using direct evidence obtained from ancient remains. © 2014 The Author(s) Published by the Royal Society. All rights reserved.
AB - An 84 base pair sequence of the Streptococcus mutansvirulence factor, known as dextranase, has been obtained from 10 individuals from the Bronze Age to the Modern Era in Europe and from before and after the colonization in America. Modern samples show four polymorphic sites that have not been found in the ancient samples studied so far. The nucleotide and haplotype diversity of this region have increased over time, which could be reflecting the footprint of a population expansion. While this segment has apparently evolved according to neutral evolution, we have been able to detect one site that is under positive selection pressure both in present and past populations. This study is a first step to study the evolution of this microorganism, analysed using direct evidence obtained from ancient remains. © 2014 The Author(s) Published by the Royal Society. All rights reserved.
KW - Dextranase
KW - Neutral evolution
KW - Positive selection
KW - Streptococcus mutans
U2 - 10.1098/rspb.2014.0586
DO - 10.1098/rspb.2014.0586
M3 - Article
SN - 0962-8452
VL - 281
JO - Proceedings of the Royal Society B: Biological Sciences
JF - Proceedings of the Royal Society B: Biological Sciences
M1 - 20140586
ER -