TY - JOUR
T1 - Modelling multiple sclerosis using induced pluripotent stem cells
AU - Martínez-Larrosa, Júlia
AU - Matute-Blanch, Clara
AU - Montalban, Xavier
AU - Comabella, Manuel
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/12/15
Y1 - 2020/12/15
N2 - Multiple Sclerosis (MS) is one of the leading causes of non-traumatic neurological disability among young adults. Due to its complex pathology and the lack of reliable disease models, there are no effective therapies for MS to prevent neurodegeneration or promote neuroprotection, and hence stop disease progression. The emergence of induced pluripotent stem cells (iPSC) has allowed the generation of patient-specific neural cell types for disease modelling, drug screening, and cell therapy. In this review, the challenges related with the use of iPSC-derived cells in MS are discussed, with a special focus on the functional studies performed, limitations and future perspectives.
AB - Multiple Sclerosis (MS) is one of the leading causes of non-traumatic neurological disability among young adults. Due to its complex pathology and the lack of reliable disease models, there are no effective therapies for MS to prevent neurodegeneration or promote neuroprotection, and hence stop disease progression. The emergence of induced pluripotent stem cells (iPSC) has allowed the generation of patient-specific neural cell types for disease modelling, drug screening, and cell therapy. In this review, the challenges related with the use of iPSC-derived cells in MS are discussed, with a special focus on the functional studies performed, limitations and future perspectives.
KW - Induced pluripotent stem cells
KW - Multiple sclerosis
KW - Neurodegeneration
KW - Neuroprotection
UR - https://www.scopus.com/pages/publications/85093704436
U2 - 10.1016/j.jneuroim.2020.577425
DO - 10.1016/j.jneuroim.2020.577425
M3 - Review article
C2 - 33130461
AN - SCOPUS:85093704436
SN - 0165-5728
VL - 349
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
M1 - 577425
ER -