@article{abb2de9b4f344bc9bc4bc5dd41c497b1,
title = "Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity",
abstract = "Tur et al. show that LPS-induced stress in macrophages requires mitofusin 2, which affects mitochondrial respiration and ROS production. The lack of Mfn2 in macrophages blocks the triggering of pro-inflammatory responses, phagocytosis, and antigen presentation.",
keywords = "apoptotic bodies, inflammation, lipopolysaccharide (LPS), macrophages, mitochondria, mitofusin, phagocytosis, protein degradation, reactive oxygen species (ROS), septic shock",
author = "Juan Tur and Selma Pereira-Lopes and Tania Vico and Mar{\'i}n, {Eros A.} and Mu{\~n}oz, {Juan P.} and Maribel Hern{\'a}ndez-Alvarez and Cardona, {Pere Joan} and Antonio Zorzano and Jorge Lloberas and Antonio Celada",
note = "Funding Information: This work was supported by Ministerio de Econom{\'i}a y Competitividad (MINECO) grants SAF2014-52887-R and BFU2017-85353 (J.L. and A.C.), MINECO grant SAF2013-40987R (A.Z.), Generalitat de Catalunya grant 2014SGR48 (A.Z.), the Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM) (A.Z.), Programa de Cooperaci{\'o}n Interregiones IV-B Europa Suroccidental (INTERREG IVB-SUDOE-FEDER) (DIOMED, SOE1/P1/E178) (A.Z.), and INFLAMES (PIE-14/00045, El Instituto de Salud Carlos III [ISCIII], Spain). A.Z. is a recipient of a Catalan Institution for Research and Advanced Studies (ICREA) “Academia” award (Generalitat de Catalunya). The Institute for Research in Biomedicine (IRB Barcelona) is recipient of the Severo Ochoa Award of Excellence from MINECO. J.T. and S.P.-L. were supported by Formaci{\'o}n del Profesorado Universitario grants AP2012-02327 and AP2010-5396, respectively, from the Ministerio de Educaci{\'o}n, Cultura y Deporte. We thank Dr. Emil R. Unanue, from the Washington University School of Medicine, St. Louis, Missouri, for reagents and advice in antigen presentation assays. We thank Dr. Neus Prats for tissue evaluation of mouse autopsies (Histopathology Core Facility, IRB Barcelona) and Nuria Elias for technical work. J.T. and J.P.M. conceived and performed the experiments and wrote the manuscript. S.P.-L. T.V. E.A.M. and M.H.-A. performed experiments. P.-J.C. provided expertise and feedback. A.Z. J.L. and A.C. conceived the experiments, wrote the manuscript, and secured funding. The authors declare no competing interests. Funding Information: This work was supported by Ministerio de Econom{\'i}a y Competitividad ( MINECO ) grants SAF2014-52887-R and BFU2017-85353 (J.L. and A.C.), MINECO grant SAF2013-40987R (A.Z.), Generalitat de Catalunya grant 2014SGR48 (A.Z.), the Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders ( CIBERDEM ) (A.Z.), Programa de Cooperaci{\'o}n Interregiones IV-B Europa Suroccidental ( INTERREG IVB-SUDOE-FEDER) ( DIOMED , SOE1/P1/E178 ) (A.Z.), and INFLAMES ( PIE-14/00045 , El Instituto de Salud Carlos III [ ISCIII ], Spain). A.Z. is a recipient of a Catalan Institution for Research and Advanced Studies ( ICREA ) “Academia” award (Generalitat de Catalunya). The Institute for Research in Biomedicine (IRB Barcelona) is recipient of the Severo Ochoa Award of Excellence from MINECO . J.T. and S.P.-L. were supported by Formaci{\'o}n del Profesorado Universitario grants AP2012-02327 and AP2010-5396 , respectively, from the Ministerio de Educaci{\'o}n, Cultura y Deporte . We thank Dr. Emil R. Unanue, from the Washington University School of Medicine, St. Louis, Missouri, for reagents and advice in antigen presentation assays. We thank Dr. Neus Prats for tissue evaluation of mouse autopsies (Histopathology Core Facility, IRB Barcelona) and Nuria Elias for technical work. Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = aug,
day = "25",
doi = "10.1016/j.celrep.2020.108079",
language = "English",
volume = "32",
journal = "Cell reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "8",
}