Methylated arginines and nitric oxide in end-stage renal disease: Impact of inflammation, oxidative stress and haemodialysis

Nadia Bouteldja; Richard J. Woodman; Chris L. Hewitson; Enric Domingo; Jeffrey A. Barbara; Arduino A. Mangoni

doi:10.3109/1354750X.2013.795608

Methylated arginines and nitric oxide in end-stage renal disease: Impact of inflammation, oxidative stress and haemodialysis

Nadia Bouteldja, Richard J. Woodman, Chris L. Hewitson, Enric Domingo, Jeffrey A. Barbara, Arduino A. Mangoni

Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

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Objectives: To determine whether inflammation (C-reactive protein, CRP), oxidative stress (malondialdehyde, MDA) or haemodialysis (HD) affect associations between asymmetric (ADMA), symmetric (SDMA) dimethylarginine, NG-monomethyl-L-arginine (L-NMMA) and nitrite/nitrate (NOx) in end-stage renal disease (ESRD). Method: Metabolites were measured pre-HD, after 1 hour and end-HD in 40 ESRD patients (age 63 ± 14 years). Results: Positive associations between NOx and ADMA (p = 0.04), SDMA (p < 0.001) and L-NMMA (p = 0.04) were observed pre-HD. Associations weakened during HD but were not significantly influenced by CRP or MDA. Conclusions: HD, oxidative stress or inflammation did not significantly affect the positive associations between methylated arginines and NOx in ESRD. © 2013 Informa UK Ltd.

Idioma original	Anglès
Pàgines (de-a)	357-364
Revista	Biomarkers
Volum	18
Número	4
DOIs	https://doi.org/10.3109/1354750X.2013.795608
Estat de la publicació	Publicada - 29 de maig 2013

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@article{634229e72e3245e3b8165b432cdf0e16,

title = "Methylated arginines and nitric oxide in end-stage renal disease: Impact of inflammation, oxidative stress and haemodialysis",

abstract = "Objectives: To determine whether inflammation (C-reactive protein, CRP), oxidative stress (malondialdehyde, MDA) or haemodialysis (HD) affect associations between asymmetric (ADMA), symmetric (SDMA) dimethylarginine, NG-monomethyl-L-arginine (L-NMMA) and nitrite/nitrate (NOx) in end-stage renal disease (ESRD). Method: Metabolites were measured pre-HD, after 1 hour and end-HD in 40 ESRD patients (age 63 ± 14 years). Results: Positive associations between NOx and ADMA (p = 0.04), SDMA (p < 0.001) and L-NMMA (p = 0.04) were observed pre-HD. Associations weakened during HD but were not significantly influenced by CRP or MDA. Conclusions: HD, oxidative stress or inflammation did not significantly affect the positive associations between methylated arginines and NOx in ESRD. {\textcopyright} 2013 Informa UK Ltd.",

keywords = "Cardiovascular disease, Metabol(n)omics, Renal disease",

author = "Nadia Bouteldja and Woodman, \{Richard J.\} and Hewitson, \{Chris L.\} and Enric Domingo and Barbara, \{Jeffrey A.\} and Mangoni, \{Arduino A.\}",

year = "2013",

month = may,

day = "29",

doi = "10.3109/1354750X.2013.795608",

language = "English",

volume = "18",

pages = "357--364",

journal = "Biomarkers",

issn = "1354-750X",

publisher = "Taylor and Francis Ltd.",

number = "4",

}

TY - JOUR

T1 - Methylated arginines and nitric oxide in end-stage renal disease: Impact of inflammation, oxidative stress and haemodialysis

AU - Bouteldja, Nadia

AU - Woodman, Richard J.

AU - Hewitson, Chris L.

AU - Domingo, Enric

AU - Barbara, Jeffrey A.

AU - Mangoni, Arduino A.

PY - 2013/5/29

Y1 - 2013/5/29

N2 - Objectives: To determine whether inflammation (C-reactive protein, CRP), oxidative stress (malondialdehyde, MDA) or haemodialysis (HD) affect associations between asymmetric (ADMA), symmetric (SDMA) dimethylarginine, NG-monomethyl-L-arginine (L-NMMA) and nitrite/nitrate (NOx) in end-stage renal disease (ESRD). Method: Metabolites were measured pre-HD, after 1 hour and end-HD in 40 ESRD patients (age 63 ± 14 years). Results: Positive associations between NOx and ADMA (p = 0.04), SDMA (p < 0.001) and L-NMMA (p = 0.04) were observed pre-HD. Associations weakened during HD but were not significantly influenced by CRP or MDA. Conclusions: HD, oxidative stress or inflammation did not significantly affect the positive associations between methylated arginines and NOx in ESRD. © 2013 Informa UK Ltd.

AB - Objectives: To determine whether inflammation (C-reactive protein, CRP), oxidative stress (malondialdehyde, MDA) or haemodialysis (HD) affect associations between asymmetric (ADMA), symmetric (SDMA) dimethylarginine, NG-monomethyl-L-arginine (L-NMMA) and nitrite/nitrate (NOx) in end-stage renal disease (ESRD). Method: Metabolites were measured pre-HD, after 1 hour and end-HD in 40 ESRD patients (age 63 ± 14 years). Results: Positive associations between NOx and ADMA (p = 0.04), SDMA (p < 0.001) and L-NMMA (p = 0.04) were observed pre-HD. Associations weakened during HD but were not significantly influenced by CRP or MDA. Conclusions: HD, oxidative stress or inflammation did not significantly affect the positive associations between methylated arginines and NOx in ESRD. © 2013 Informa UK Ltd.

KW - Cardiovascular disease

KW - Metabol(n)omics

KW - Renal disease

UR - https://www.scopus.com/pages/publications/84878117446

U2 - 10.3109/1354750X.2013.795608

DO - 10.3109/1354750X.2013.795608

M3 - Article

SN - 1354-750X

VL - 18

SP - 357

EP - 364

JO - Biomarkers

JF - Biomarkers

IS - 4

ER -

Methylated arginines and nitric oxide in end-stage renal disease: Impact of inflammation, oxidative stress and haemodialysis

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