Metabolic effects of chronic ACTH administration, interaction with response to stress

A. Armario; L. Campmany; J. Hidalgo

doi:10.1159/000138221

Metabolic effects of chronic ACTH administration, interaction with response to stress

A. Armario, L. Campmany, J. Hidalgo

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El present experiment es va dur a terme per estudiar la resposta metabòlica a l'estrès de rates mascles tractades amb ACTH de manera crònica o aguda. Es va trobar que les rates tractades amb ACTH de manera crònica mostraven una lleugera reducció en el consum d'aliment i un decrement del guany de pes corporal. Aquest tractament incrementava els nivells basals de triglicèrids sèrics i insulina. A més, es van trobar algunes diferències en la resposta a l'estrès en les rates tractades amb ACTH crònicament. Així doncs, aquests animals, a diferència dels altres dos grups, mostraven una disminució del nivell circulant de triglicèrids i insulina com a resposta a un estrès a curt termini. A més, 24 hores després d'un episodi d'estrès es va trobar en les rates tractades amb ACTH crònicament una caiguda més pronunciada del pes hepàtic i els nivells de glucosa. Això suggereix que el tractament crònic amb ACTH podria alterar la resposta metabòlica a un estrès agut prolongat, fet que podria resultar en una menor resistència als grans esforços. © 1986 S. Karger AG, Basel.

Idioma original	Anglès
Pàgines (de-a)	235-240
Revista	Pharmacology
Volum	33
DOIs	https://doi.org/10.1159/000138221
Estat de la publicació	Publicada - 1 de gen. 1986

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@article{54f5d24518d743dc8c5c2055110d1563,

title = "Metabolic effects of chronic ACTH administration, interaction with response to stress",

abstract = "The present experiment was undertaken to study the metabolic response to stress of single or chronic ACTH-treated male rats. It was found that chronic ACTH-treated rats showed a slight reduction in food intake and a decrease in body weight gain. This treatment increased basal serum triglyceride and insulin levels. In addition, some differences in response to stress was found in chronic ACTH-treated rats. Thus, these latter animals, unlike the other two groups, showed a decrease in circulating triglyceride and insulin levels in response to short-term stress. Moreover, 24 h after onset of stress a more marked fall in liver weight and glucose levels were found in chronic ACTH-treated rats. It suggests that chronic ACTH treatment might alter the metabolic response to prolonged acute stress what could result in lower resistance to severe stresses. {\textcopyright} 1986 S. Karger AG, Basel.",

keywords = "ACTH treatment, Free fatty acids, Glucose, Insulin, Stress, Triglyceride",

author = "A. Armario and L. Campmany and J. Hidalgo",

year = "1986",

month = jan,

day = "1",

doi = "10.1159/000138221",

language = "English",

volume = "33",

pages = "235--240",

journal = "Pharmacology",

issn = "0031-7012",

}

TY - JOUR

T1 - Metabolic effects of chronic ACTH administration, interaction with response to stress

AU - Armario, A.

AU - Campmany, L.

AU - Hidalgo, J.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - The present experiment was undertaken to study the metabolic response to stress of single or chronic ACTH-treated male rats. It was found that chronic ACTH-treated rats showed a slight reduction in food intake and a decrease in body weight gain. This treatment increased basal serum triglyceride and insulin levels. In addition, some differences in response to stress was found in chronic ACTH-treated rats. Thus, these latter animals, unlike the other two groups, showed a decrease in circulating triglyceride and insulin levels in response to short-term stress. Moreover, 24 h after onset of stress a more marked fall in liver weight and glucose levels were found in chronic ACTH-treated rats. It suggests that chronic ACTH treatment might alter the metabolic response to prolonged acute stress what could result in lower resistance to severe stresses. © 1986 S. Karger AG, Basel.

AB - The present experiment was undertaken to study the metabolic response to stress of single or chronic ACTH-treated male rats. It was found that chronic ACTH-treated rats showed a slight reduction in food intake and a decrease in body weight gain. This treatment increased basal serum triglyceride and insulin levels. In addition, some differences in response to stress was found in chronic ACTH-treated rats. Thus, these latter animals, unlike the other two groups, showed a decrease in circulating triglyceride and insulin levels in response to short-term stress. Moreover, 24 h after onset of stress a more marked fall in liver weight and glucose levels were found in chronic ACTH-treated rats. It suggests that chronic ACTH treatment might alter the metabolic response to prolonged acute stress what could result in lower resistance to severe stresses. © 1986 S. Karger AG, Basel.

KW - ACTH treatment

KW - Free fatty acids

KW - Glucose

KW - Insulin

KW - Stress

KW - Triglyceride

UR - https://www.scopus.com/pages/publications/0022551861

U2 - 10.1159/000138221

DO - 10.1159/000138221

M3 - Article

SN - 0031-7012

VL - 33

SP - 235

EP - 240

JO - Pharmacology

JF - Pharmacology

ER -

Metabolic effects of chronic ACTH administration, interaction with response to stress

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