TY - JOUR
T1 - Matrix metaloproteinases in neurological brain lesions: A new therapeutic target?
AU - Vilalta, Anna
AU - Sahuquillo, Joan
AU - Poca, M. Antonia
PY - 2010/7/16
Y1 - 2010/7/16
N2 - Introduction. Matrix metalloproteinases (MMP) are a family of proteolytic enzymes that degrade the extracellular matrix and are found in a large amount of human tissues. Their main functions are to maintain the integrity of the extracellular matrix, to modulate the interaction of the cells during development, to contribute to tissue remodeling, to directly participate in angiogenesis and to facilitate cellular migration. Due to the importance of its maintaining extracellular matrix function, MMP expression is tightly regulated at transcriptional level, through proform activation and with the binding to tissular inhibitors. Despite this complex regulation system, MMP regulation can be altered, producing an overexpression of these proteolytic proteins that alter the tissular structure, possibly destroying the tissue, as observed in some neurologic pathologies such as multiple sclerosis, aneurism formation and cerebral ischemia. The role that MMP have in traumatic brain lesions is almost unknown and is derived mainly from in vivo and in vitro experimental studies, and only from three papers performed in humans. There are some experimental studies that relate the brain alterations produced after traumatic brain injury with an increase in the concentration of various MMP. Aim. To review the role of these proteases in human brain lesions, emphasizing on the function of these proteases in traumatic brain injury lesions and their possible therapeutic target. Development. A bibliographic search was performed on Medline database. Conclusions. Some MMP could be related to blood-brain barrier alteration and postraumatic edema formation, turning them into promising therapeutic targets. © 2010 Revista de Neurología.
AB - Introduction. Matrix metalloproteinases (MMP) are a family of proteolytic enzymes that degrade the extracellular matrix and are found in a large amount of human tissues. Their main functions are to maintain the integrity of the extracellular matrix, to modulate the interaction of the cells during development, to contribute to tissue remodeling, to directly participate in angiogenesis and to facilitate cellular migration. Due to the importance of its maintaining extracellular matrix function, MMP expression is tightly regulated at transcriptional level, through proform activation and with the binding to tissular inhibitors. Despite this complex regulation system, MMP regulation can be altered, producing an overexpression of these proteolytic proteins that alter the tissular structure, possibly destroying the tissue, as observed in some neurologic pathologies such as multiple sclerosis, aneurism formation and cerebral ischemia. The role that MMP have in traumatic brain lesions is almost unknown and is derived mainly from in vivo and in vitro experimental studies, and only from three papers performed in humans. There are some experimental studies that relate the brain alterations produced after traumatic brain injury with an increase in the concentration of various MMP. Aim. To review the role of these proteases in human brain lesions, emphasizing on the function of these proteases in traumatic brain injury lesions and their possible therapeutic target. Development. A bibliographic search was performed on Medline database. Conclusions. Some MMP could be related to blood-brain barrier alteration and postraumatic edema formation, turning them into promising therapeutic targets. © 2010 Revista de Neurología.
KW - Blood-brain barrier
KW - Cerebral ischemia
KW - Extracellular matrix
KW - Matrix metalloproteinases
KW - Neuroinflammation
KW - Traumatic brain injury
M3 - Review article
SN - 0210-0010
VL - 51
SP - 95
EP - 107
JO - Revista de Neurologia
JF - Revista de Neurologia
IS - 2
ER -