TY - JOUR
T1 - Management of squamous cell carcinoma of the head and neck
T2 - Updated European treatment recommendations
AU - Ramos, Monica
AU - Benavente, Sergi
AU - Giralt, Jordi
PY - 2010/3
Y1 - 2010/3
N2 - Squamous cell carcinoma of the head and neck requires a multidisciplinary management. Risk factors for adjuvant radiotherapy are stage III-IV, perineural involvement or vascular tumor embolism. If there are positive margins or extracapsular extension chemoradiotherapy is needed. For patients with nonresectable disease we recommend treatment with concomitant chemoradiation, although this has important acute and late toxicity. Concomitant EGF receptor inhibitors and taxane-based induction chemotherapy are new strategies under study that have demonstrated some benefits but are not yet the standard treatment. Intensity-modulated radiotherapy allows one to decrease radiation dose to organs. Preclinical work in signaling pathways and other oncogenic factors (e.g., human papillomavirus infection) will be the key to improving outcomes of head and neck cancer patients in the future.
AB - Squamous cell carcinoma of the head and neck requires a multidisciplinary management. Risk factors for adjuvant radiotherapy are stage III-IV, perineural involvement or vascular tumor embolism. If there are positive margins or extracapsular extension chemoradiotherapy is needed. For patients with nonresectable disease we recommend treatment with concomitant chemoradiation, although this has important acute and late toxicity. Concomitant EGF receptor inhibitors and taxane-based induction chemotherapy are new strategies under study that have demonstrated some benefits but are not yet the standard treatment. Intensity-modulated radiotherapy allows one to decrease radiation dose to organs. Preclinical work in signaling pathways and other oncogenic factors (e.g., human papillomavirus infection) will be the key to improving outcomes of head and neck cancer patients in the future.
KW - EGF receptor
KW - Head and neck cancer
KW - Human papillomavirus
KW - Intensity-modulated radiotherapy
KW - Locally advanced head and neck carcinoma
KW - Postoperative radiotherapy
KW - Risk groups
KW - Squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=77949428730&partnerID=8YFLogxK
U2 - 10.1586/ERA.10.6
DO - 10.1586/ERA.10.6
M3 - Review article
C2 - 20214515
AN - SCOPUS:77949428730
SN - 1473-7140
VL - 10
SP - 339
EP - 344
JO - Expert Review of Anticancer Therapy
JF - Expert Review of Anticancer Therapy
IS - 3
ER -