Low and Oscillatory Wall Shear Stress Is Not Related to Aortic Dilation in Patients With Bicuspid Aortic Valve

Lydia Dux-Santoy, Andrea Guala, Julio Sotelo, Sergio Uribe, Gisela Teixido-Tura, Aroa Ruiz-Muñoz, Daniel E. Hurtado, Filipa Valente, Laura Galian-Gay, Laura Gutiérrez García-Moreno, Teresa González-Alujas, Kevin M. Johnson, Oliver Wieben, Ignacio Ferreira-Gonzalez, Arturo Evangelista Masip, Jose F Rodriguez-Palomares

Producció científica: Contribució a revistaArticleRecercaAvaluat per experts

25 Cites (Scopus)

Resum

Supplemental Digital Content is available in the text. To assess the relationship between regional wall shear stress (WSS) and oscillatory shear index (OSI) and aortic dilation in patients with bicuspid aortic valve (BAV). Forty-six consecutive patients with BAV (63% with right-left-coronary-cusp fusion, aortic diameter ≤ 45 mm and no severe valvular disease) and 44 healthy volunteers were studied by time-resolved 3-dimensional phase-contrast magnetic resonance imaging. WSS and OSI were quantified at different levels of the ascending aorta and the aortic arch, and regional WSS and OSI maps were obtained. Seventy percent of BAV had ascending aorta dilation. Compared with healthy volunteers, patients with BAV had increased WSS and decreased OSI in most of the ascending aorta and the aortic arch. In both BAV and healthy volunteers, regions of high WSS matched regions of low OSI and vice versa. No regions of both low WSS and high OSI were identified in BAV compared with healthy volunteers. Patients with BAV with dilated compared with nondilated aorta presented low and oscillatory WSS in the aortic arch, but not in the ascending aorta where dilation is more prevalent. Furthermore, no regions of concomitant low WSS and high OSI were identified when BAV were compared according to leaflet fusion pattern, despite the well-known differences in regional dilation prevalence. Regions with low WSS and high OSI do not match those with the highest prevalence of dilation in patients with BAV, thus providing no evidence to support the low and oscillatory shear stress theory in the pathogenesis of proximal aorta dilation in the presence of BAV.
Idioma originalAnglès
Pàgines (de-a)e10-e20
RevistaArteriosclerosis and Thrombosis
Volum40
DOIs
Estat de la publicacióPublicada - 2019

Fingerprint

Navegar pels temes de recerca de 'Low and Oscillatory Wall Shear Stress Is Not Related to Aortic Dilation in Patients With Bicuspid Aortic Valve'. Junts formen un fingerprint únic.

Com citar-ho