Loss of heterozygosity on chromosome 13q12-q14, BRCA-2 mutations and lack of BRCA-2 promoter hypermethylation in sporadic epithelial ovarian tumors

Keyphrases

• BRCA2 100%
• Loss of Heterozygosity 100%
• Promoter Methylation 100%
• Epithelial Ovarian Tumor 100%
• Tumor 63%
• Ovarian Carcinoma 45%
• Breast Cancer Susceptibility Gene 1 (BRCA1) 36%
• Tumor Suppressor Gene 27%
• Carcinoma 27%
• Serous 18%
• Ovarian Tumor 18%
• Tumor Suppressor 9%
• Germ Cells 9%
• Breast 9%
• Tumor Tissue 9%
• Methylation 9%
• Germline mutation 9%
• American Cancer Society 9%
• Frameshift 9%
• Polymerase Chain Reaction Analysis 9%
• Microsatellite Loci 9%
• Fresh-frozen 9%
• Nonsense 9%
• Isochromosome 17q 9%
• Borderline Tumor 9%
• Protein Truncation 9%
• Family Cancer History 9%
• Tumor-normal 9%
• Methylation-specific Polymerase Chain Reaction 9%
• Single-strand Conformation Polymorphism Analysis 9%
• Two-hit 9%
• Hereditary Predisposition 9%
• Chromosome 13q 9%

Biochemistry, Genetics and Molecular Biology

• Loss of Heterozygosity 100%
• Promoter Region 100%
• Methylation 42%
• Tumor Suppressor Gene 42%
• Germline 14%
• Single-Strand Conformation Polymorphism 14%
• Tumor Suppressor Protein 14%
• Germ Cell 14%
• Germline Mutation 14%
• Chromosome 17q 14%
• Chromosome 13q 14%
• Microsatellite 14%
• Polymerase Chain Reaction 14%