Locked-in syndrome of reversible clinical course

A 72-year-old female developed a "locked-in" syndrome due to bilateral ventral pontine infarction. The symptoms improved 72 hours after the beginning of the clinical features. At the end of the acute phase of the disease, only a pseudobulbar syndrome of pontocerebellar type persisted. Usually, the evolution of "locked-in" syndrome is irreversible. However, our case shows that a satisfactory outcome can be possible, with a partial regression of the initially established neurological symptoms.