TY - JOUR
T1 - Language in young females with fragile X syndrome
T2 - Influence on the neurocognitive profile and adaptive behavior
AU - Joga-Elvira, Lorena
AU - Roche-Martínez, Ana
AU - Joga, María Luisa
AU - Jacas-Escarcelle, Carlos
AU - Brun-Gasca, Carme
N1 - © 2021 Wiley Periodicals LLC.
PY - 2021/2/18
Y1 - 2021/2/18
N2 - Fragile X syndrome (FXS) is the leading cause of inherited intellectual disability. The objective of this research is to analyze the relationship between linguistic functions and performance of the following neuropsychological functions: executive, quantitative reasoning, social perception, behavior, social skills, and adaptive behavior. A neuropsychological and behavioral evaluations were carried out with a group of 26 girls with FXS, and 14 girls without FXS as a control group, using standardized tests. The two groups were homogeneous in age and IQ. Significant differences were found between groups in the relationship between some language processes: inhibition, auditory working memory, cognitive flexibility, level of social adaptation, self-direction, conceptual adaptation, academic skills, leadership ability, theory of mind, and arithmetic. In the group of girls with FXS, it was found that different aspects of language influence some of the executive functions evaluated, in addition to some specific aspects of social perception, adaptive behavior, and quantitative reasoning, in different ways. Future research should incorporate the study of the influence of other cognitive variables such as visual perception and executive function on behavioral, social, and adaptive aspects to know the real influence of all the cognitive variables on the behavior of girls with FXS.
AB - Fragile X syndrome (FXS) is the leading cause of inherited intellectual disability. The objective of this research is to analyze the relationship between linguistic functions and performance of the following neuropsychological functions: executive, quantitative reasoning, social perception, behavior, social skills, and adaptive behavior. A neuropsychological and behavioral evaluations were carried out with a group of 26 girls with FXS, and 14 girls without FXS as a control group, using standardized tests. The two groups were homogeneous in age and IQ. Significant differences were found between groups in the relationship between some language processes: inhibition, auditory working memory, cognitive flexibility, level of social adaptation, self-direction, conceptual adaptation, academic skills, leadership ability, theory of mind, and arithmetic. In the group of girls with FXS, it was found that different aspects of language influence some of the executive functions evaluated, in addition to some specific aspects of social perception, adaptive behavior, and quantitative reasoning, in different ways. Future research should incorporate the study of the influence of other cognitive variables such as visual perception and executive function on behavioral, social, and adaptive aspects to know the real influence of all the cognitive variables on the behavior of girls with FXS.
KW - behavior
KW - cognition
KW - females
KW - fragile-X syndrome
KW - language
KW - Humans
KW - Social Perception/psychology
KW - Social Skills
KW - Social Behavior
KW - Adolescent
KW - Intellectual Disability/complications
KW - Female
KW - Speech-Language Pathology
KW - Adaptation, Psychological/physiology
KW - Child
KW - Fragile X Syndrome/complications
UR - http://www.scopus.com/inward/record.url?scp=85100953236&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/b1131c7d-5947-3733-a6b7-eb61234e822d/
U2 - 10.1002/ajmg.a.62130
DO - 10.1002/ajmg.a.62130
M3 - Article
C2 - 33605062
AN - SCOPUS:85100953236
SN - 1552-4825
VL - 185
SP - 1448
EP - 1460
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
IS - 5
ER -