Lack of association of SDF-1 3′ A variant allele with long-term nonprogressive HIV-1 infection is extended beyond 16 years

Francesc Vidal; Joaquim Peraire; Pere Domingo; Montserrat Broch; Hernando Knobel; Enric Pedrol; David Dalmau; Consuelo Viladés; Antònia Sambeat; Cristina Gutiérrez; Cristóbal Richart

doi:10.1097/01.qai.0000176653.89769.4d

Lack of association of SDF-1 3′ A variant allele with long-term nonprogressive HIV-1 infection is extended beyond 16 years

Francesc Vidal^*, Joaquim Peraire, Pere Domingo, Montserrat Broch, Hernando Knobel, Enric Pedrol, David Dalmau, Consuelo Viladés, Antònia Sambeat, Cristina Gutiérrez, Cristóbal Richart

^*Autor corresponent d’aquest treball

Departament de Medicina

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Resum

We studied the frequency of the SDF-1 3′ A allelic variant (80IG→A) in a cohort of white Spaniards made up of (1) HIV-1-infected long-term nonprogressors (LTNPs) older than 16 years of age (n = 57), (2) HIV-1-infected usual progressors (UPs; n = 107). and (3) a group of healthy controls (n = 100). The mutant SDF-1 3′ A allele was observed in 28% of LTNPs, 19% of UPs. and 26% of healthy controls (P = not significant). Homozygosity for the 3′ A mutation was detected in 7%. 4%, and 3% of LTNPs, UPs, and healthy controls, respectively (P = not significant). Polymorphism at the SDF-1 locus is not associated with LTNP disease of longer than 16 years in Spanish HIV-1-infected patients. This effect is independent of the CCR5Δ32 allele.

Idioma original	Anglès
Pàgines (de-a)	276-279
Nombre de pàgines	4
Revista	Journal of acquired immune deficiency syndromes (1999)
Volum	40
Número	3
DOIs	https://doi.org/10.1097/01.qai.0000176653.89769.4d https://doi.org/10.1097/01.qai.0000176653.89769.4d
Estat de la publicació	Publicada - 1 de nov. 2005

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Vidal, F., Peraire, J., Domingo, P., Broch, M., Knobel, H., Pedrol, E., Dalmau, D., Viladés, C., Sambeat, A., Gutiérrez, C., & Richart, C. (2005). Lack of association of SDF-1 3′ A variant allele with long-term nonprogressive HIV-1 infection is extended beyond 16 years. Journal of acquired immune deficiency syndromes (1999), 40(3), 276-279. https://doi.org/10.1097/01.qai.0000176653.89769.4d, https://doi.org/10.1097/01.qai.0000176653.89769.4d

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title = "Lack of association of SDF-1 3′ A variant allele with long-term nonprogressive HIV-1 infection is extended beyond 16 years",

abstract = "We studied the frequency of the SDF-1 3′ A allelic variant (80IG→A) in a cohort of white Spaniards made up of (1) HIV-1-infected long-term nonprogressors (LTNPs) older than 16 years of age (n = 57), (2) HIV-1-infected usual progressors (UPs; n = 107). and (3) a group of healthy controls (n = 100). The mutant SDF-1 3′ A allele was observed in 28% of LTNPs, 19% of UPs. and 26% of healthy controls (P = not significant). Homozygosity for the 3′ A mutation was detected in 7%. 4%, and 3% of LTNPs, UPs, and healthy controls, respectively (P = not significant). Polymorphism at the SDF-1 locus is not associated with LTNP disease of longer than 16 years in Spanish HIV-1-infected patients. This effect is independent of the CCR5Δ32 allele.",

keywords = "CCR5Δ32, Genetic polymorphism, HIV-1 infection, Long-term nonprogressors, SDF-1 3′ A",

author = "Francesc Vidal and Joaquim Peraire and Pere Domingo and Montserrat Broch and Hernando Knobel and Enric Pedrol and David Dalmau and Consuelo Vilad{\'e}s and Ant{\`o}nia Sambeat and Cristina Guti{\'e}rrez and Crist{\'o}bal Richart",

year = "2005",

month = nov,

day = "1",

doi = "10.1097/01.qai.0000176653.89769.4d",

language = "English",

volume = "40",

pages = "276--279",

number = "3",

}

Vidal, F, Peraire, J, Domingo, P, Broch, M, Knobel, H, Pedrol, E, Dalmau, D, Viladés, C, Sambeat, A, Gutiérrez, C & Richart, C 2005, 'Lack of association of SDF-1 3′ A variant allele with long-term nonprogressive HIV-1 infection is extended beyond 16 years', Journal of acquired immune deficiency syndromes (1999), vol. 40, núm. 3, pàg. 276-279. https://doi.org/10.1097/01.qai.0000176653.89769.4d, https://doi.org/10.1097/01.qai.0000176653.89769.4d

Lack of association of SDF-1 3′ A variant allele with long-term nonprogressive HIV-1 infection is extended beyond 16 years. / Vidal, Francesc; Peraire, Joaquim; Domingo, Pere et al.
In: Journal of acquired immune deficiency syndromes (1999), Vol. 40, Núm. 3, 01.11.2005, pàg. 276-279.

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

TY - JOUR

T1 - Lack of association of SDF-1 3′ A variant allele with long-term nonprogressive HIV-1 infection is extended beyond 16 years

AU - Vidal, Francesc

AU - Peraire, Joaquim

AU - Domingo, Pere

AU - Broch, Montserrat

AU - Knobel, Hernando

AU - Pedrol, Enric

AU - Dalmau, David

AU - Viladés, Consuelo

AU - Sambeat, Antònia

AU - Gutiérrez, Cristina

AU - Richart, Cristóbal

PY - 2005/11/1

Y1 - 2005/11/1

N2 - We studied the frequency of the SDF-1 3′ A allelic variant (80IG→A) in a cohort of white Spaniards made up of (1) HIV-1-infected long-term nonprogressors (LTNPs) older than 16 years of age (n = 57), (2) HIV-1-infected usual progressors (UPs; n = 107). and (3) a group of healthy controls (n = 100). The mutant SDF-1 3′ A allele was observed in 28% of LTNPs, 19% of UPs. and 26% of healthy controls (P = not significant). Homozygosity for the 3′ A mutation was detected in 7%. 4%, and 3% of LTNPs, UPs, and healthy controls, respectively (P = not significant). Polymorphism at the SDF-1 locus is not associated with LTNP disease of longer than 16 years in Spanish HIV-1-infected patients. This effect is independent of the CCR5Δ32 allele.

AB - We studied the frequency of the SDF-1 3′ A allelic variant (80IG→A) in a cohort of white Spaniards made up of (1) HIV-1-infected long-term nonprogressors (LTNPs) older than 16 years of age (n = 57), (2) HIV-1-infected usual progressors (UPs; n = 107). and (3) a group of healthy controls (n = 100). The mutant SDF-1 3′ A allele was observed in 28% of LTNPs, 19% of UPs. and 26% of healthy controls (P = not significant). Homozygosity for the 3′ A mutation was detected in 7%. 4%, and 3% of LTNPs, UPs, and healthy controls, respectively (P = not significant). Polymorphism at the SDF-1 locus is not associated with LTNP disease of longer than 16 years in Spanish HIV-1-infected patients. This effect is independent of the CCR5Δ32 allele.

KW - CCR5Δ32

KW - Genetic polymorphism

KW - HIV-1 infection

KW - Long-term nonprogressors

KW - SDF-1 3′ A

UR - http://www.scopus.com/inward/record.url?scp=27444441921&partnerID=8YFLogxK

U2 - 10.1097/01.qai.0000176653.89769.4d

DO - 10.1097/01.qai.0000176653.89769.4d

M3 - Article

C2 - 16249700

SN - 1525-4135

VL - 40

SP - 276

EP - 279

JO - Journal of acquired immune deficiency syndromes (1999)

JF - Journal of acquired immune deficiency syndromes (1999)

IS - 3

ER -

Lack of association of SDF-1 3′ A variant allele with long-term nonprogressive HIV-1 infection is extended beyond 16 years

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