Kinetic studies of N-allenic analogues of tryptamine as monoamine oxidase inhibitors

V. Perez, J. L. Marco, E. Fernandez-Alvarez, M. Unzeta

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Resum

A series of N-allenic analogues of tryptamine in which the side chain is located at the 2 position of the indole ring, but which differed in the ring and side-chain nitrogen substituents, were assayed kinetically as MAO A and MAO B inhibitors. All the compounds studied were mechanism-based inhibitors. The kinetic constants of each inhibition step K(i) and k(i), were determined for both MAO A and B. The data obtained indicated that these allenic derivatives show a greater selectivity and potency towards MAO A as inhibitors than the corresponding acetylenic derivatives.
Idioma originalAnglès
Pàgines (de-a)718-722
RevistaJournal of Pharmacy and Pharmacology
Volum48
Número7
DOIs
Estat de la publicacióPublicada - 1 de gen. 1996

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