TY - JOUR
T1 - Kinetic studies of N-allenic analogues of tryptamine as monoamine oxidase inhibitors
AU - Perez, V.
AU - Marco, J. L.
AU - Fernandez-Alvarez, E.
AU - Unzeta, M.
PY - 1996/1/1
Y1 - 1996/1/1
N2 - A series of N-allenic analogues of tryptamine in which the side chain is located at the 2 position of the indole ring, but which differed in the ring and side-chain nitrogen substituents, were assayed kinetically as MAO A and MAO B inhibitors. All the compounds studied were mechanism-based inhibitors. The kinetic constants of each inhibition step K(i) and k(i), were determined for both MAO A and B. The data obtained indicated that these allenic derivatives show a greater selectivity and potency towards MAO A as inhibitors than the corresponding acetylenic derivatives.
AB - A series of N-allenic analogues of tryptamine in which the side chain is located at the 2 position of the indole ring, but which differed in the ring and side-chain nitrogen substituents, were assayed kinetically as MAO A and MAO B inhibitors. All the compounds studied were mechanism-based inhibitors. The kinetic constants of each inhibition step K(i) and k(i), were determined for both MAO A and B. The data obtained indicated that these allenic derivatives show a greater selectivity and potency towards MAO A as inhibitors than the corresponding acetylenic derivatives.
U2 - 10.1111/j.2042-7158.1996.tb03958.x
DO - 10.1111/j.2042-7158.1996.tb03958.x
M3 - Article
SN - 0022-3573
VL - 48
SP - 718
EP - 722
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
IS - 7
ER -