TY - JOUR
T1 - Juvenile neuroaxonal dystrophy in a Rottweiler: Accumulation of synaptic proteins in dystrophic axons
AU - Pumarola Batlle, Marti
AU - Sisó, S.
AU - Ferrer, I.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Dystrophic axons in a 2-year-old male Rottweiler with neuroaxonal dystrophy have shown synaptophysin, synapsin-I, synaptosomal-associated protein of 25 kDa (SNAP-25), Rab 3a, and α-synuclein immunoreactivity. Similar findings have been observed in isolated dystrophic axons in the nuclei gracillis and cunneatus in five dogs aged between 14 and 18 years. Abnormal expression of integral synaptic vesicle, synaptic vesicle-associated presynaptic plasma membrane and cytosolic proteins, which participate in the trafficking, docking and fusion of the synaptic vesicle to the plasma membrane, suggest severe disruption of axonal transport in dystrophic axons in canine neuroaxonal dystrophy.
AB - Dystrophic axons in a 2-year-old male Rottweiler with neuroaxonal dystrophy have shown synaptophysin, synapsin-I, synaptosomal-associated protein of 25 kDa (SNAP-25), Rab 3a, and α-synuclein immunoreactivity. Similar findings have been observed in isolated dystrophic axons in the nuclei gracillis and cunneatus in five dogs aged between 14 and 18 years. Abnormal expression of integral synaptic vesicle, synaptic vesicle-associated presynaptic plasma membrane and cytosolic proteins, which participate in the trafficking, docking and fusion of the synaptic vesicle to the plasma membrane, suggest severe disruption of axonal transport in dystrophic axons in canine neuroaxonal dystrophy.
KW - Neuroaxonal dystrophy
KW - Rottweiler
KW - SNAP-25
KW - Synapsin-I
KW - Synaptophysin
UR - https://www.scopus.com/pages/publications/0034769106
U2 - 10.1007/s004010100386
DO - 10.1007/s004010100386
M3 - Article
SN - 0001-6322
VL - 102
SP - 501
EP - 504
JO - Acta Neuropathologica
JF - Acta Neuropathologica
IS - 5
ER -