TY - JOUR
T1 - Ischemic stroke patients are biologically older than their chronological age
AU - Soriano-Tárraga, Carolina
AU - Giralt-Steinhauer, Eva
AU - Mola-Caminal, Marina
AU - Vivanco-Hidalgo, Rosa M.
AU - Ois, Angel
AU - Rodríguez-Campello, Ana
AU - Cuadrado-Godia, Elisa
AU - Sayols-Baixeras, Sergi
AU - Elosua, Roberto
AU - Roquer, Jaume
AU - Jiménez-Conde, Jordi
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Ischemic stroke is associated with aging. It is possible to predict chronological age by measuring age-related changes in DNA methylation from multiple CpG sites across the genome, known as biological age. The difference between biological age and actual chronological age would indicate an individual's level of aging. Our aim was to determine the biological age of ischemic stroke patients and compare their aging with controls of the same chronological age. A total of 123 individuals, 41 controls and 82 patients with ischemic stroke were paired by chronological age, ranging from 39 to 82 years. Illumina HumanMethylation450 BeadChip array was used to measure DNA methylation in CpG sites in both groups, and biological age was estimated using methylation values of specific CpGs. Ischemic stroke patients were biologically an average 2.5 years older than healthy controls (p-value=0.010). Stratified by age tertiles, younger stroke patients (≤57 years old) were biologically older than controls (OR=1.19; 95%CI 1.00-1.41, p-value=0.046). The older groups showed no biological age differences between cases and controls, but were close to reaching the significance level. Ischemic stroke patients are biologically older than controls. Biological age should be considered as a potential new biomarker of stroke risk.
AB - Ischemic stroke is associated with aging. It is possible to predict chronological age by measuring age-related changes in DNA methylation from multiple CpG sites across the genome, known as biological age. The difference between biological age and actual chronological age would indicate an individual's level of aging. Our aim was to determine the biological age of ischemic stroke patients and compare their aging with controls of the same chronological age. A total of 123 individuals, 41 controls and 82 patients with ischemic stroke were paired by chronological age, ranging from 39 to 82 years. Illumina HumanMethylation450 BeadChip array was used to measure DNA methylation in CpG sites in both groups, and biological age was estimated using methylation values of specific CpGs. Ischemic stroke patients were biologically an average 2.5 years older than healthy controls (p-value=0.010). Stratified by age tertiles, younger stroke patients (≤57 years old) were biologically older than controls (OR=1.19; 95%CI 1.00-1.41, p-value=0.046). The older groups showed no biological age differences between cases and controls, but were close to reaching the significance level. Ischemic stroke patients are biologically older than controls. Biological age should be considered as a potential new biomarker of stroke risk.
KW - Aging
KW - Biological age
KW - DNA methylation
KW - Epigenetics
KW - Ischemic stroke
U2 - 10.18632/aging.101028
DO - 10.18632/aging.101028
M3 - Article
SN - 1945-4589
VL - 8
SP - 2655
EP - 2666
JO - Aging
JF - Aging
IS - 11
ER -