Is it possible to predict late antepartum stillbirth by means of cerebroplacental ratio and maternal characteristics?

José Morales-Roselló, Alberto Galindo, Ignacio Herraiz, María M. Gil, Maia Brik Spinelli, Catalina De Paco-Matallana, Ricardo Ciammela, Carlos Sánchez Ajenjo, Antonio José Cañada Martínez, Juan Luís Delgado, Alfredo Perales-Marín

Producció científica: Contribució a revistaArticleRecercaAvaluat per experts

9 Cites (Scopus)

Resum

Objective: To examine the potential value of fetal ultrasound and maternal characteristics in the prediction of antepartum stillbirth after 32 weeks’ gestation.

Methods: This was a retrospective multicenter study in Spain. In 29 pregnancies, umbilical artery pulsatility index (UA PI), middle cerebral artery pulsatility index (MCA PI), cerebroplacental ratio (CPR), estimated fetal weight (EFW), and maternal characteristics were recorded within 15 days prior to a stillbirth. The values of UA PI, MCA PI, and CPR were converted into multiples of the normal median (MoM) for gestational age and the EFW was expressed as percentile according to a Spanish reference range for gestational age. Data from the 29 pregnancies with stillbirths and 2298 control pregnancies resulting in livebirths were compared and multivariate logistic regression analysis was used to determine significant predictors of stillbirth.

Results: The only significant predictor of stillbirth was CPR (OR = 0.161, 95% confidence interval [CI] 0.035, 0.654; p = .014); the area under the receiver operating characteristics curve was 0.663 (95% CI 0.545, 0.782) and the detection rate (DR) was 32.14% at a 10% false-positive rate (FPR). In addition, when we included MCA and UA PI MoM instead of CPR, only MCA PI MoM was significant (OR = 0.104, 95% confidence interval [CI] 0.013, 0.735; p = .029), with similar prediction abilities (area under the curve (AUC) 0.645, DR 28.6%, FPR 10%).

Conclusions: The CPR and MCA PI are predictors of late stillbirth but the performance of prediction is poor.
Idioma originalAnglès
Pàgines (de-a)2996-3002
Nombre de pàgines7
RevistaJournal of Maternal-Fetal and Neonatal Medicine
Volum33
Número17
DOIs
Estat de la publicacióPublicada - 2020

Fingerprint

Navegar pels temes de recerca de 'Is it possible to predict late antepartum stillbirth by means of cerebroplacental ratio and maternal characteristics?'. Junts formen un fingerprint únic.

Com citar-ho