Is experimental catalepsy properly measured?

S. Ferré, T. Guix, G. Prat, F. Jane, M. Casas

Producció científica: Contribució a una revistaArticleRecercaAvaluat per experts

97 Cites (Scopus)

Resum

Following logarithmic transformation (ln) of total duration of haloperidol-induced catalepsy in the rat, measured by means of the bar test, a normalization of the results is achieved. With the help of this transformation we have been able to study what are probably the most important variables involved in the measuring of experimental catalepsy and to establish some criteria for a better use of such measures: 1) repeated measures of catalepsy have to be taken in order to avoid the stress-induced inhibition of catalepsy caused by the new experimental situation, 2) the dose of neuroleptic used has to be sufficiently low to permit the measurement of total or real duration of catalepsy between two determinations, and 3) the dose of neuroleptic has to be sufficiently high to prevent the development of a learned "pseudocatalepsy.". © 1990.
Idioma originalEnglish
Pàgines (de-a)753-757
RevistaPharmacology, Biochemistry and Behavior
Volum35
Número4
DOIs
Estat de la publicacióPublicada - 1 de gen. 1990

Fingerprint

Navegar pels temes de recerca de 'Is experimental catalepsy properly measured?'. Junts formen un fingerprint únic.

Com citar-ho