TY - JOUR
T1 - [Interobserver variability in the evaluation of functional systems and Kurzke expanded disability status scale in a multiple sclerosis patient]
AU - Montalban, X
AU - Tintoré, M
AU - Río, J
AU - Galán, I
AU - Codina, A
PY - 1996/6
Y1 - 1996/6
N2 - Changes in the progression of disability is still the main variable measured in clinical trials involving patients with multiple sclerosis (EM). The amplified scale of the state of disability (EEDA) of Kurtzke continues to be the most widely used scale. One of the most important limitations of the EEDA is interobserver variability. The object of our study was to find the interobserver variability between members of our EM unit in patients with EEDA between 0 and 3.5 when applying functional systems (SF) and EEDA. Seven patients with recurrent remittent EM (EEDA 0-3.5), participating in a multicentric trial with natural beta-interferon, were assessed monthly for 12 months by two of four neurologists. The SF were assessed and the EEDA applied separately and without knowing the former. 80 paired examinations were made. Complete concordance of SF was only seen when a variation of 2 points was allowed, while it was very high for a variation of 0 and 1 points. Complete concordance for EEDA was seen in 36.6% of the cases and only in 11% was there discordance of 1 or 1.5 points. The average variability of EDSS was 0.39. There was greater variability when the two scores were at different levels of incapacity.
AB - Changes in the progression of disability is still the main variable measured in clinical trials involving patients with multiple sclerosis (EM). The amplified scale of the state of disability (EEDA) of Kurtzke continues to be the most widely used scale. One of the most important limitations of the EEDA is interobserver variability. The object of our study was to find the interobserver variability between members of our EM unit in patients with EEDA between 0 and 3.5 when applying functional systems (SF) and EEDA. Seven patients with recurrent remittent EM (EEDA 0-3.5), participating in a multicentric trial with natural beta-interferon, were assessed monthly for 12 months by two of four neurologists. The SF were assessed and the EEDA applied separately and without knowing the former. 80 paired examinations were made. Complete concordance of SF was only seen when a variation of 2 points was allowed, while it was very high for a variation of 0 and 1 points. Complete concordance for EEDA was seen in 36.6% of the cases and only in 11% was there discordance of 1 or 1.5 points. The average variability of EDSS was 0.39. There was greater variability when the two scores were at different levels of incapacity.
UR - http://europepmc.org/abstract/med/8653604
UR - https://www.scopus.com/pages/publications/0030160272
M3 - Article
C2 - 8653604
SN - 0210-0010
VL - 24
SP - 630
EP - 632
JO - Revista de Neurologia
JF - Revista de Neurologia
IS - 130
ER -