TY - JOUR
T1 - Interaction Between Orexin-A and Sleep Quality in Females in Extreme Weight Conditions
AU - Sauchelli, Sarah
AU - Jiménez-Murcia, Susana
AU - Fernández-García, Jose C.
AU - Garrido-Sánchez, Lourdes
AU - Tinahones, Francisco J.
AU - Casanueva, Felipe F.
AU - Baños, Rosa M.
AU - Botella, Cristina
AU - Crujeiras, Ana B.
AU - de la Torre, Rafael
AU - Fernández-Real, Jose M.
AU - Frühbeck, Gema
AU - Granero, Roser
AU - Ortega, Francisco J.
AU - Rodríguez, Amaia
AU - Zipfel, Stephan
AU - Giel, Katrin E.
AU - Menchón, Jose M.
AU - Fernández-Aranda, Fernando
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association. The current study examined the relationship between plasma orexin-A and sleep in obesity. Concentrations of orexin-A and sleep were evaluated in 26 obese, 40 morbid obese and 32 healthy-weight participants. The sleep monitor Actiwatch AW7 and the Pittsburgh Sleep Quality Index were used to evaluate sleep. The Symptom Checklist-90-Revised was administered to assess symptoms of psychopathology. A higher weight status was associated with elevated orexin-A levels (p =.050), greater depression, anxiety and somatization symptoms (all: p <.001), and impoverished self-reported sleep quality (p <.001). A quadratic trend was found in objective sleep time, being longest in the obese group (p =.031). Structural equation modelling showed plasma orexin-A to be related to poor total sleep quality, which in turn was associated with elevated body mass index. Our data confirm an interaction between elevated plasma orexin-A concentrations and poor sleep that contributes to fluctuations in body mass index. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.
AB - Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association. The current study examined the relationship between plasma orexin-A and sleep in obesity. Concentrations of orexin-A and sleep were evaluated in 26 obese, 40 morbid obese and 32 healthy-weight participants. The sleep monitor Actiwatch AW7 and the Pittsburgh Sleep Quality Index were used to evaluate sleep. The Symptom Checklist-90-Revised was administered to assess symptoms of psychopathology. A higher weight status was associated with elevated orexin-A levels (p =.050), greater depression, anxiety and somatization symptoms (all: p <.001), and impoverished self-reported sleep quality (p <.001). A quadratic trend was found in objective sleep time, being longest in the obese group (p =.031). Structural equation modelling showed plasma orexin-A to be related to poor total sleep quality, which in turn was associated with elevated body mass index. Our data confirm an interaction between elevated plasma orexin-A concentrations and poor sleep that contributes to fluctuations in body mass index. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.
KW - body mass index
KW - obesity
KW - orexin
KW - sleep
UR - https://www.scopus.com/pages/publications/84992445375
U2 - 10.1002/erv.2484
DO - 10.1002/erv.2484
M3 - Article
SN - 1072-4133
VL - 24
SP - 510
EP - 517
JO - European Eating Disorders Review
JF - European Eating Disorders Review
IS - 6
ER -
