Integrated gene expression profiles reveal a transcriptomic network underlying the thermogenic response in adipose tissue

Miquel Garcia, Sylvie Franckhauser, Veronica Jimenez, Fàtima Bosch i Tubert, Jordi Rodó, Estefania Casaña Lorente, Sergio Muñoz, Claudia Jambrina Pallares, Victor Sacristan, Ignasi Grass Costa

Producció científica: Contribució a una revistaArticleRecercaAvaluat per experts

1 Citació (Scopus)

Resum

Obesity and type 2 diabetes are two closely related diseases representing a serious threat worldwide. An increase in metabolic rate through enhancement of non-shivering thermogenesis in adipose tissue may represent a potential therapeutic strategy. Nevertheless, a better understanding of thermogenesis transcriptional regulation is needed to allow the development of new effective treatments. Here, we aimed to characterize the specific transcriptomic response of white and brown adipose tissues after thermogenic induction. Using cold exposure to induce thermogenesis in mice, we identified mRNAs and miRNAs that were differentially expressed in several adipose depots. In addition, integration of transcriptomic data in regulatory networks of miRNAs and transcription factors allowed the identification of key nodes likely controlling metabolism and immune response. Moreover, we identified the putative role of the transcription factor PU.1 in the regulation of PPARγ-mediated thermogenic response of subcutaneous white adipose tissue. Therefore, the present study provides new insights into the molecular mechanisms that regulate non-shivering thermogenesis.
Idioma originalEnglish
RevistaScientific Reports
Volum13
DOIs
Estat de la publicacióPublicada - 2023

Fingerprint

Navegar pels temes de recerca de 'Integrated gene expression profiles reveal a transcriptomic network underlying the thermogenic response in adipose tissue'. Junts formen un fingerprint únic.

Com citar-ho