Insulin-like growth factor 2 overexpression induces β-Cell dysfunction and increases beta-cell susceptibility to damage

Alba Casellas; Cristina Mallol; Ariana Salavert; Veronica Jimenez; Miquel Garcia; Judith Agudo; Mercè Obach; Virginia Haurigot; Laia Vilà; Maria Molas; Ricardo Lage; Meritxell Morro; Estefania Casana; Jesús Ruberte; Fatima Bosch

doi:10.1074/jbc.M115.642041

Insulin-like growth factor 2 overexpression induces β-Cell dysfunction and increases beta-cell susceptibility to damage

Alba Casellas, Cristina Mallol, Ariana Salavert, Veronica Jimenez, Miquel Garcia, Judith Agudo, Mercè Obach, Virginia Haurigot, Laia Vilà, Maria Molas, Ricardo Lage, Meritxell Morro, Estefania Casana, Jesús Ruberte, Fatima Bosch

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Background: Human and animal studies have shown associations between insulin growth factor 2 (IGF2) and diabetes. Results: Overexpression of insulin growth factor 2 in β -cells leads to β -cell dysfunction and makes islets more vulnerable to β -cell damage and immune attack. Conclusion: IGF2 may play an important role in the predisposition and development of diabetes. Significance: This study unravels an unprecedented role of IGF2 on physiology of β-cells.

Idioma original	Anglès
Pàgines (de-a)	16772-16785
Revista	Journal of Biological Chemistry
Volum	290
Número	27
DOIs	https://doi.org/10.1074/jbc.M115.642041
Estat de la publicació	Publicada - 3 de jul. 2015

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10.1074/jbc.M115.642041

https://ddd.uab.cat/record/173890

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Casellas, A., Mallol, C., Salavert, A., Jimenez, V., Garcia, M., Agudo, J., Obach, M., Haurigot, V., Vilà, L., Molas, M., Lage, R., Morro, M., Casana, E., Ruberte, J., & Bosch, F. (2015). Insulin-like growth factor 2 overexpression induces β-Cell dysfunction and increases beta-cell susceptibility to damage. Journal of Biological Chemistry, 290(27), 16772-16785. https://doi.org/10.1074/jbc.M115.642041

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title = "Insulin-like growth factor 2 overexpression induces β-Cell dysfunction and increases beta-cell susceptibility to damage",

abstract = "{\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Background: Human and animal studies have shown associations between insulin growth factor 2 (IGF2) and diabetes. Results: Overexpression of insulin growth factor 2 in β -cells leads to β -cell dysfunction and makes islets more vulnerable to β -cell damage and immune attack. Conclusion: IGF2 may play an important role in the predisposition and development of diabetes. Significance: This study unravels an unprecedented role of IGF2 on physiology of β-cells.",

author = "Alba Casellas and Cristina Mallol and Ariana Salavert and Veronica Jimenez and Miquel Garcia and Judith Agudo and Merc{\`e} Obach and Virginia Haurigot and Laia Vil{\`a} and Maria Molas and Ricardo Lage and Meritxell Morro and Estefania Casana and Jes{\'u}s Ruberte and Fatima Bosch",

year = "2015",

month = jul,

day = "3",

doi = "10.1074/jbc.M115.642041",

language = "English",

volume = "290",

pages = "16772--16785",

number = "27",

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Casellas, A, Mallol, C, Salavert, A, Jimenez, V, Garcia, M, Agudo, J, Obach, M, Haurigot, V, Vilà, L, Molas, M, Lage, R, Morro, M, Casana, E, Ruberte, J & Bosch, F 2015, 'Insulin-like growth factor 2 overexpression induces β-Cell dysfunction and increases beta-cell susceptibility to damage', Journal of Biological Chemistry, vol. 290, núm. 27, pàg. 16772-16785. https://doi.org/10.1074/jbc.M115.642041

TY - JOUR

T1 - Insulin-like growth factor 2 overexpression induces β-Cell dysfunction and increases beta-cell susceptibility to damage

AU - Casellas, Alba

AU - Mallol, Cristina

AU - Salavert, Ariana

AU - Jimenez, Veronica

AU - Garcia, Miquel

AU - Agudo, Judith

AU - Obach, Mercè

AU - Haurigot, Virginia

AU - Vilà, Laia

AU - Molas, Maria

AU - Lage, Ricardo

AU - Morro, Meritxell

AU - Casana, Estefania

AU - Ruberte, Jesús

AU - Bosch, Fatima

PY - 2015/7/3

Y1 - 2015/7/3

N2 - © 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Background: Human and animal studies have shown associations between insulin growth factor 2 (IGF2) and diabetes. Results: Overexpression of insulin growth factor 2 in β -cells leads to β -cell dysfunction and makes islets more vulnerable to β -cell damage and immune attack. Conclusion: IGF2 may play an important role in the predisposition and development of diabetes. Significance: This study unravels an unprecedented role of IGF2 on physiology of β-cells.

AB - © 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Background: Human and animal studies have shown associations between insulin growth factor 2 (IGF2) and diabetes. Results: Overexpression of insulin growth factor 2 in β -cells leads to β -cell dysfunction and makes islets more vulnerable to β -cell damage and immune attack. Conclusion: IGF2 may play an important role in the predisposition and development of diabetes. Significance: This study unravels an unprecedented role of IGF2 on physiology of β-cells.

U2 - 10.1074/jbc.M115.642041

DO - 10.1074/jbc.M115.642041

M3 - Article

SN - 0021-9258

VL - 290

SP - 16772

EP - 16785

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 27

ER -

Insulin-like growth factor 2 overexpression induces β-Cell dysfunction and increases beta-cell susceptibility to damage

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