TY - JOUR
T1 - Inspiratory Muscle Function and Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction
AU - Palau, Patricia
AU - Domínguez, Eloy
AU - Núñez, Eduardo
AU - Ramón, Jose María
AU - López, Laura
AU - Melero, Joana
AU - Bellver, Alejandro
AU - Chorro, Francisco J.
AU - Bodí, Vicent
AU - Bayés-Genis, Antoni
AU - Sanchis, Juan
AU - Núñez, Julio
PY - 2017/6/1
Y1 - 2017/6/1
N2 - © 2017 Elsevier Inc. Background Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome characterized by impaired exercise capacity resulting from dyspnea and fatigue. The pathophysiological mechanisms underlying the exercise intolerance in HFpEF are not well established. We sought to evaluate the effects of inspiratory muscle function on exercise tolerance in symptomatic patients with HFpEF. Methods and Results A total of 74 stable symptomatic patients with HFpEF and New York Heart Association class II-III underwent a cardiopulmonary exercise test between June 2012 and May 2016. Inspiratory muscle weakness was defined as maximum inspiratory pressure (MIP) <70% of normal predicted values. Pearson correlation coefficient and multivariate linear regression analysis were used to assess the association between percent of predicted MIP (pp-MIP) and maximal exercise capacity [measured by peak oxygen uptake (peak VO2) and percent of predicted peak VO2 (pp-peak VO2)]. Thirty-one patients (42%) displayed inspiratory muscle weakness. Mean (standard deviation) age was 72.5 ± 9.1 years, 53% were women, and 35.1% displayed New York Heart Association class III. Mean peak VO2 and pp-peak VO2 were 10 ± 2.8 mL•min•kg and 57.3 ± 13.8%, respectively. The median (interquartile range) of pp-MIP was 72% (58%–90%). pp-MIP was not correlated with peak VO2 (r = −0.047, P = .689) nor pp-peak VO2 (r = −0.078, P = .509). Furthermore, in multivariable analysis, pp-MIP showed no association with peak VO2 (β coefficient = 0.01, 95% confidence interval −0.01 to 0.03, P = .241) and pp-peak VO2 (β coefficient = −0.00, 95% confidence interval −0.10 to 0.10, P = .975). Conclusions In symptomatic elderly patients with HFpEF, we found that pp-MIP was not associated with either peak VO2 or pp-peak VO2.
AB - © 2017 Elsevier Inc. Background Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome characterized by impaired exercise capacity resulting from dyspnea and fatigue. The pathophysiological mechanisms underlying the exercise intolerance in HFpEF are not well established. We sought to evaluate the effects of inspiratory muscle function on exercise tolerance in symptomatic patients with HFpEF. Methods and Results A total of 74 stable symptomatic patients with HFpEF and New York Heart Association class II-III underwent a cardiopulmonary exercise test between June 2012 and May 2016. Inspiratory muscle weakness was defined as maximum inspiratory pressure (MIP) <70% of normal predicted values. Pearson correlation coefficient and multivariate linear regression analysis were used to assess the association between percent of predicted MIP (pp-MIP) and maximal exercise capacity [measured by peak oxygen uptake (peak VO2) and percent of predicted peak VO2 (pp-peak VO2)]. Thirty-one patients (42%) displayed inspiratory muscle weakness. Mean (standard deviation) age was 72.5 ± 9.1 years, 53% were women, and 35.1% displayed New York Heart Association class III. Mean peak VO2 and pp-peak VO2 were 10 ± 2.8 mL•min•kg and 57.3 ± 13.8%, respectively. The median (interquartile range) of pp-MIP was 72% (58%–90%). pp-MIP was not correlated with peak VO2 (r = −0.047, P = .689) nor pp-peak VO2 (r = −0.078, P = .509). Furthermore, in multivariable analysis, pp-MIP showed no association with peak VO2 (β coefficient = 0.01, 95% confidence interval −0.01 to 0.03, P = .241) and pp-peak VO2 (β coefficient = −0.00, 95% confidence interval −0.10 to 0.10, P = .975). Conclusions In symptomatic elderly patients with HFpEF, we found that pp-MIP was not associated with either peak VO2 or pp-peak VO2.
KW - exercise capacity
KW - Heart failure with preserved ejection fraction
KW - inspiratory muscle function
U2 - 10.1016/j.cardfail.2017.04.016
DO - 10.1016/j.cardfail.2017.04.016
M3 - Article
SN - 1071-9164
VL - 23
SP - 480
EP - 484
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
IS - 6
ER -