TY - JOUR
T1 - Influence of perinatal inflammation on the neurodevelopmental outcome of premature infants
AU - Rodriguez-Trujillo, Adriano
AU - Rios, Jose
AU - Angeles, Martina A.
AU - Posadas, David E.
AU - Murillo, Clara
AU - Rueda, Claudia
AU - Botet, Francesc
AU - Bosch, Jordi
AU - Vergara, Andrea
AU - Gratacos, Eduard
AU - Palacio, Montse
AU - Cobo, Teresa
PY - 2019
Y1 - 2019
N2 - Objective: To evaluate the influence of perinatal inflammation on neurodevelopmental outcome of premature infants. Study design: From a retrospective cohort study of women with preterm labor with intact membranes or preterm prelabor rupture of membranes (PPROM) with an amniocentesis to rule out intra-amniotic inflammation (IAI) and microbial invasion of the amniotic cavity (MIAC), we evaluated neurodevelopmental outcome of their infants born between 24.0 and 34.0 weeks gestation. Women with clinical chorioamnionitis at admission were excluded. Neurodevelopmental outcome was screened with the Ages & Stages Questionnaire (ASQ)-3. We analyzed the relationship between an altered ASQ-3 and antenatal, intra-partum and post-partum factors related to perinatal inflammation. Result: Among 98 infants evaluated, 22% had an abnormal score. Amniotic fluid interleukin-6 levels and early-onset sepsis (EOS) were independent factors of an altered ASQ-3 with delivery Conclusions: In premature infants, the presence of IAI, delivery <26.0 weeks and EOS were found to be independent factors of an altered ASQ-3.
AB - Objective: To evaluate the influence of perinatal inflammation on neurodevelopmental outcome of premature infants. Study design: From a retrospective cohort study of women with preterm labor with intact membranes or preterm prelabor rupture of membranes (PPROM) with an amniocentesis to rule out intra-amniotic inflammation (IAI) and microbial invasion of the amniotic cavity (MIAC), we evaluated neurodevelopmental outcome of their infants born between 24.0 and 34.0 weeks gestation. Women with clinical chorioamnionitis at admission were excluded. Neurodevelopmental outcome was screened with the Ages & Stages Questionnaire (ASQ)-3. We analyzed the relationship between an altered ASQ-3 and antenatal, intra-partum and post-partum factors related to perinatal inflammation. Result: Among 98 infants evaluated, 22% had an abnormal score. Amniotic fluid interleukin-6 levels and early-onset sepsis (EOS) were independent factors of an altered ASQ-3 with delivery Conclusions: In premature infants, the presence of IAI, delivery <26.0 weeks and EOS were found to be independent factors of an altered ASQ-3.
KW - Infants
KW - Outcomes
KW - Women
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=uab_pure&SrcAuth=WosAPI&KeyUT=WOS:000455223500004&DestLinkType=FullRecord&DestApp=WOS
UR - https://www.scopus.com/pages/publications/85034237808
U2 - 10.1080/14767058.2017.1399118
DO - 10.1080/14767058.2017.1399118
M3 - Article
C2 - 29082789
SN - 1476-7058
VL - 32
SP - 1069
EP - 1077
JO - Journal of Maternal-Fetal & Neonatal Medicine
JF - Journal of Maternal-Fetal & Neonatal Medicine
IS - 7
ER -