Influence of concomitant food intake on the excretion of orally administered myo-inositol hexaphosphate in humans

myo-Inositol hexaphosphate (InsP 6 ) widely occurs in plant seeds. At present, some important benefits of InsP 6 for human health have been described. The purpose of this study was to find the best condition for the optimum absorption of orally administered InsP 6 , evaluated by InsP 6 urinary excretion. The influence of different stomach conditions (empty, empty with an alkalinizing agent, and full stomach) on the effects of oral administration of InsP 6 and its urinary excretion was investigated in six healthy subjects on an InsP 6 -poor diet, given 400 mg of calcium/magnesium salt of InsP 6 as a single dose. The basal urinary excretion of InsP 6 on an InsP 6 -poor diet (50.91 ± 15.09 μg) was significantly lower than that found when an InsP 6 -normal diet was consumed (100.09 ± 26.42 μg) (P < .05). No differences were observed in the areas under the curve of accumulated excretion at 8 hours among the three different stomach conditions studied, suggesting that the over-all InsP 6 absorption took place independently of the stomach state (full or fasted) and indicating that the InsP 6 absorption also takes place during the intestinal transit. Thus, if InsP 6 supplements of vegetal origin are consumed to maintain the optimum InsP 6 levels needed for a healthy status, these supplements can be consumed either during or between meals with the same efficacy. © Mary Ann Liebert, Inc.