TY - JOUR
T1 - Inflammatory myopathy: Diagnosis and clinical course, specific clinical scenarios and new complementary tools
AU - Selva-O'callaghan, Albert
AU - Trallero-Araguás, Ernesto
AU - Martínez, Maria Angeles
AU - Labrador-Horrillo, Moises
AU - Pinal-Fernández, Iago
AU - Grau-Junyent, Josep Maria
AU - Juárez, Candido
PY - 2015/1/1
Y1 - 2015/1/1
N2 - © 2015 Informa UK, Ltd. Idiopathic inflammatory myopathies are a heterogeneous group of rare autoimmune diseases characterized by symmetric proximal muscle weakness and inflammatory infiltrates on muscle biopsy. A meticulously collected combination of clinical, serological, and pathological data is essential to correctly diagnose and classify myositis patients, often a considerable challenge for clinicians. This article provides a comprehensive overview of the most useful tools for the diagnosis and follow-up of patients with myositis. Capillaroscopy, serological biomarkers (particularly the autoantibody profile) and imaging techniques, such as muscle magnetic resonance and chest ultrasound, are of great aid in diagnosing, classifying and managing these patients. Relevant clinical scenarios, such as interstitial lung disease, associated cancer and pregnancy are also addressed in this review. Myositis registries, identification of new autoantibodies, and genetic studies will enhance our understanding of the pathogenesis of these conditions and help to define new diagnostic and therapeutic approaches.
AB - © 2015 Informa UK, Ltd. Idiopathic inflammatory myopathies are a heterogeneous group of rare autoimmune diseases characterized by symmetric proximal muscle weakness and inflammatory infiltrates on muscle biopsy. A meticulously collected combination of clinical, serological, and pathological data is essential to correctly diagnose and classify myositis patients, often a considerable challenge for clinicians. This article provides a comprehensive overview of the most useful tools for the diagnosis and follow-up of patients with myositis. Capillaroscopy, serological biomarkers (particularly the autoantibody profile) and imaging techniques, such as muscle magnetic resonance and chest ultrasound, are of great aid in diagnosing, classifying and managing these patients. Relevant clinical scenarios, such as interstitial lung disease, associated cancer and pregnancy are also addressed in this review. Myositis registries, identification of new autoantibodies, and genetic studies will enhance our understanding of the pathogenesis of these conditions and help to define new diagnostic and therapeutic approaches.
KW - autoantibodies
KW - classification
KW - dermatomyositis
KW - diagnosis
KW - idiopathic inflammatory myopathies
KW - myositis
KW - polymyositis
U2 - 10.1586/1744666X.2015.1035258
DO - 10.1586/1744666X.2015.1035258
M3 - Review article
SN - 1744-666X
VL - 11
SP - 737
EP - 747
JO - Expert Review of Clinical Immunology
JF - Expert Review of Clinical Immunology
IS - 6
ER -