TY - JOUR
T1 - Induction of c-Fos expression by electrical stimulation of the nucleus basalis magnocellularis
AU - Boix-Trelis, Núria
AU - Vale-Martínez, Anna
AU - Guillazo-Blanch, Gemma
AU - Martí-Nicolovius, Margarita
PY - 2009/1/9
Y1 - 2009/1/9
N2 - The present study examined the expression of the immediate-early gene c-fos in different brain regions following a single 20-min session of unilateral electrical stimulation of the nucleus basalis magnocellularis (NBM). Current findings confirm that NBM stimulation provides specific activation of several cortical and subcortical regions closely related to the NBM and involved in learning and memory processes, such as the cingulate, parietal, piriform and perirhinal cortices, dorsal subiculum, and the parafascicular, central lateral and central medial nuclei of the thalamus. In contrast, NBM stimulation did not increase c-Fos expression in some expected areas that receive direct NBM projections such as the entorhinal cortex or amygdala nuclei. Results are discussed in terms of the possibility that NBM electrical stimulation facilitates learning by inducing neural changes related to transcription factors such as c-Fos. © 2008 Elsevier Ireland Ltd. All rights reserved.
AB - The present study examined the expression of the immediate-early gene c-fos in different brain regions following a single 20-min session of unilateral electrical stimulation of the nucleus basalis magnocellularis (NBM). Current findings confirm that NBM stimulation provides specific activation of several cortical and subcortical regions closely related to the NBM and involved in learning and memory processes, such as the cingulate, parietal, piriform and perirhinal cortices, dorsal subiculum, and the parafascicular, central lateral and central medial nuclei of the thalamus. In contrast, NBM stimulation did not increase c-Fos expression in some expected areas that receive direct NBM projections such as the entorhinal cortex or amygdala nuclei. Results are discussed in terms of the possibility that NBM electrical stimulation facilitates learning by inducing neural changes related to transcription factors such as c-Fos. © 2008 Elsevier Ireland Ltd. All rights reserved.
KW - Basal forebrain
KW - Electrical stimulation
KW - Immediate-early gene expression
KW - Learning and memory
KW - Nucleus basalis magnocellularis
KW - Rat
UR - https://www.scopus.com/pages/publications/56949106766
U2 - 10.1016/j.neulet.2008.10.105
DO - 10.1016/j.neulet.2008.10.105
M3 - Article
SN - 0304-3940
VL - 449
SP - 137
EP - 141
JO - Neuroscience Letters
JF - Neuroscience Letters
ER -