Resum
The effect of chronic treatment (10 days) with thioridazine (25 mg/kg per day, i.p.) on the increase in diastolic blood pressure induced by methoxamine and xylazine was studied in the pithed rat. The dose-response curve for methoxamine, but not for xylazine, was shifted to the left by the neuroleptic. These results indicate that postjunctional α1-adrenoceptors in the rat blood vessels become supersentitive after long-term treatment with thioridazine. © 1989.
Idioma original | Anglès |
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Pàgines (de-a) | 111-113 |
Revista | European Journal of Pharmacology |
Volum | 168 |
Número | 1 |
DOIs | |
Estat de la publicació | Publicada - 1 de set. 1989 |