Increased peripheral α<inf>1</inf>-adrenoceptor sensitivity following chronic thioridazine treatment in the pithed rat

Maria Laura Cuffí, Elisabet Vila, Albert Badia

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    Resum

    The effect of chronic treatment (10 days) with thioridazine (25 mg/kg per day, i.p.) on the increase in diastolic blood pressure induced by methoxamine and xylazine was studied in the pithed rat. The dose-response curve for methoxamine, but not for xylazine, was shifted to the left by the neuroleptic. These results indicate that postjunctional α1-adrenoceptors in the rat blood vessels become supersentitive after long-term treatment with thioridazine. © 1989.
    Idioma originalEnglish
    Pàgines (de-a)111-113
    RevistaEuropean Journal of Pharmacology
    Volum168
    Número d'incidència1
    DOIs
    Estat de la publicacióPublicada - 1 de set. 1989

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