TY - JOUR
T1 - Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients: An expert taskforce review
AU - Garciá-Foncillas, Jesús
AU - Alba, E.
AU - Aranda, E.
AU - Diáz-Rubio, E.
AU - López-López, R.
AU - Tabernero, J.
AU - Vivancos, A.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - © The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. The importance of mutation identification for advanced colorectal cancer treatment with anti-epidermal growth factor receptor agents is well established. However, due to delays in turnaround time, low-quality tissue samples, and/or lack of standardization of testing methods a significant proportion of patients are being treated without the information that Kirsten rat sarcoma and neuroblastoma rat sarcoma (RAS) testing can provide. The detection of mutated circulating tumor DNA by BEAMing technology addresses this gap in care and allows these patients to receive international guideline-recommended expanded RAS testing with rapid turnaround times. Furthermore, the overall concordance between OncoBEAM RAS colorectal cancer testing and standard of care tissue testing is very high (93.3%). This article presents an overview of the clinical utility and potential applications of this minimally invasive method, such as early detection of emergent resistance to anti-epidermal growth factor receptor therapy. If appropriately implemented, BEAMing technology holds considerable promise to enhance the quality of patient care and improve clinical outcomes.
AB - © The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. The importance of mutation identification for advanced colorectal cancer treatment with anti-epidermal growth factor receptor agents is well established. However, due to delays in turnaround time, low-quality tissue samples, and/or lack of standardization of testing methods a significant proportion of patients are being treated without the information that Kirsten rat sarcoma and neuroblastoma rat sarcoma (RAS) testing can provide. The detection of mutated circulating tumor DNA by BEAMing technology addresses this gap in care and allows these patients to receive international guideline-recommended expanded RAS testing with rapid turnaround times. Furthermore, the overall concordance between OncoBEAM RAS colorectal cancer testing and standard of care tissue testing is very high (93.3%). This article presents an overview of the clinical utility and potential applications of this minimally invasive method, such as early detection of emergent resistance to anti-epidermal growth factor receptor therapy. If appropriately implemented, BEAMing technology holds considerable promise to enhance the quality of patient care and improve clinical outcomes.
KW - Colorectal cancer
KW - EGFR
KW - Liquid biopsy
KW - Mutation testing
KW - Tumor resistance
UR - https://www.scopus.com/pages/publications/85042150457
U2 - 10.1093/annonc/mdx501
DO - 10.1093/annonc/mdx501
M3 - Review article
SN - 0923-7534
VL - 28
SP - 2943
EP - 2949
JO - Annals of Oncology
JF - Annals of Oncology
IS - 12
ER -
