TY - JOUR
T1 - In vitro susceptibilities of bloodstream isolates of Candida species to six antifungal agents: Results from a population-based active surveillance programme, Barcelona, Spain, 2002-2003
AU - Cuenca-Estrella, Manuel
AU - Rodriguez, Dolores
AU - Almirante, Benito
AU - Morgan, Juliette
AU - Planes, Ana Maria
AU - Almela, Manel
AU - Mensa, José
AU - Sanchez, Ferran
AU - Ayats, Josefina
AU - Gimenez, Montserrat
AU - Salvado, Margarita
AU - Warnock, David W.
AU - Pahissa, Albert
AU - Rodriguez-Tuleda, Juan L.
AU - Fridkin, Scott
AU - Hajjeh, Rana
AU - Park, Benjamin
AU - Reverter, Francesc Marco
AU - Soler, Melcion
AU - Saballs, P.
AU - Gener, Amadeu
AU - Fontanals, Dionisia
AU - Xercavins, Mariona
AU - Falgueras, Lluis
AU - de Ramon, Marta
AU - Torroella, Maria Teresa
AU - Alonso, Carles
AU - Sierra, Montserrat
AU - Martinez-Montauti, Joaquin
AU - Morera, Maria Antonia
AU - de Otero, Jordi
PY - 2005/2/1
Y1 - 2005/2/1
N2 - Objectives: The antifungal drug susceptibilities of 351 isolates of Candida species, obtained through active laboratory-based surveillance in the period January 2002-December 2003, were determined (Candida albicans 51%, Candida parapsilosis 23%, Candida tropicalis 10%, Candida glabrata 9%, Candida krusei 4%). Methods: The MICs of amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole and caspofungin were established by means of the broth microdilution reference procedure of the European Committee on Antibiotic Susceptibility Testing. Results and conclusions: Amphotericin B and flucytosine were active in vitro against all strains. A total of 24 isolates (6.8%) showed decreased susceptibility to fluconazole (MIC ≥ 16 mg/L) and 43 (12.3%) showed decreased susceptibility to itraconazole (MIC ≥ 0.25 mg/L). Voriconazole and caspofungin were active in vitro against the majority of isolates, even those that were resistant to fluconazole. © The British Society for Antimicrobial Chemotherapy 2004; all rights reserved.
AB - Objectives: The antifungal drug susceptibilities of 351 isolates of Candida species, obtained through active laboratory-based surveillance in the period January 2002-December 2003, were determined (Candida albicans 51%, Candida parapsilosis 23%, Candida tropicalis 10%, Candida glabrata 9%, Candida krusei 4%). Methods: The MICs of amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole and caspofungin were established by means of the broth microdilution reference procedure of the European Committee on Antibiotic Susceptibility Testing. Results and conclusions: Amphotericin B and flucytosine were active in vitro against all strains. A total of 24 isolates (6.8%) showed decreased susceptibility to fluconazole (MIC ≥ 16 mg/L) and 43 (12.3%) showed decreased susceptibility to itraconazole (MIC ≥ 0.25 mg/L). Voriconazole and caspofungin were active in vitro against the majority of isolates, even those that were resistant to fluconazole. © The British Society for Antimicrobial Chemotherapy 2004; all rights reserved.
KW - Caspofungin
KW - EUCAST
KW - Fluconazole resistance
KW - Voriconazole
UR - https://www.scopus.com/pages/publications/20044386681
U2 - 10.1093/jac/dkh548
DO - 10.1093/jac/dkh548
M3 - Article
SN - 0305-7453
VL - 55
SP - 194
EP - 199
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
IS - 2
ER -