In vitro characterization of an Fe<inf>8</inf> cluster as potential MRI contrast agent

Elisenda Rodríguez; Anna Roig; Elies Molins; Carles Arús; María Rosa Quintero; Miquel E. Cabañas; Sebastián Cerdán; Pilar Lopez-Larrubia; Coral Sanfeliu

doi:10.1002/nbm.959

In vitro characterization of an Fe<inf>8</inf> cluster as potential MRI contrast agent

Elisenda Rodríguez, Anna Roig, Elies Molins, Carles Arús, María Rosa Quintero, Miquel E. Cabañas, Sebastián Cerdán, Pilar Lopez-Larrubia, Coral Sanfeliu

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The complex [(tacn)6Fe8 (μ3-O) 2(μ2 -OH)12] Br8·9H2O(Fe8) was evaluated in vitro as a new kind of possible MRI contrast agent. Relaxivities were measured at 1.41 and 9.4 T for Fe8 and commercial Gd-DTPA dissolved in PBS. There was significant difference for r1 and r2 values between Fe8 and Gd-DTPA at high field (9.4 T) and for r1 at low field (1.4 T) (p < 0.05). Phantom studies with T1-weighted MRI at 9.4 T suggest T1 contrast potential for Fe8. That is, up to 5.2 times higher intensity enhancement with respect to that of equimolar Gd-DTPA was obtained with an Fe8 concentration, referred to the whole molecule, of 0.2 mM, for which no toxicity on C6 cells could be detected. No toxic effects on cultured C6 cells were observed up to a concentration of 1 mM Fe8. Copyright © 2005 John Wiley & Sons, Ltd.

Idioma original	Anglès
Pàgines (de-a)	300-307
Revista	NMR in Biomedicine
Volum	18
DOIs	https://doi.org/10.1002/nbm.959
Estat de la publicació	Publicada - 1 d’ag. 2005

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10.1002/nbm.959

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@article{c5c6150b8d9444bda1a9cfce5e8aab16,

title = "In vitro characterization of an Fe8 cluster as potential MRI contrast agent",

abstract = "The complex [(tacn)6Fe8 (μ3-O) 2(μ2 -OH)12] Br8·9H2O(Fe8) was evaluated in vitro as a new kind of possible MRI contrast agent. Relaxivities were measured at 1.41 and 9.4 T for Fe8 and commercial Gd-DTPA dissolved in PBS. There was significant difference for r1 and r2 values between Fe8 and Gd-DTPA at high field (9.4 T) and for r1 at low field (1.4 T) (p < 0.05). Phantom studies with T1-weighted MRI at 9.4 T suggest T1 contrast potential for Fe8. That is, up to 5.2 times higher intensity enhancement with respect to that of equimolar Gd-DTPA was obtained with an Fe8 concentration, referred to the whole molecule, of 0.2 mM, for which no toxicity on C6 cells could be detected. No toxic effects on cultured C6 cells were observed up to a concentration of 1 mM Fe8. Copyright {\textcopyright} 2005 John Wiley & Sons, Ltd.",

keywords = "Contrast agent, Fe 8, Magnetic resonance imaging, Molecular magnets",

author = "Elisenda Rodr{\'i}guez and Anna Roig and Elies Molins and Carles Ar{\'u}s and Quintero, {Mar{\'i}a Rosa} and Caba{\~n}as, {Miquel E.} and Sebasti{\'a}n Cerd{\'a}n and Pilar Lopez-Larrubia and Coral Sanfeliu",

year = "2005",

month = aug,

day = "1",

doi = "10.1002/nbm.959",

language = "English",

volume = "18",

pages = "300--307",

journal = "NMR in Biomedicine",

issn = "0952-3480",

publisher = "John Wiley and Sons Ltd",

}

TY - JOUR

T1 - In vitro characterization of an Fe8 cluster as potential MRI contrast agent

AU - Rodríguez, Elisenda

AU - Roig, Anna

AU - Molins, Elies

AU - Arús, Carles

AU - Quintero, María Rosa

AU - Cabañas, Miquel E.

AU - Cerdán, Sebastián

AU - Lopez-Larrubia, Pilar

AU - Sanfeliu, Coral

PY - 2005/8/1

Y1 - 2005/8/1

N2 - The complex [(tacn)6Fe8 (μ3-O) 2(μ2 -OH)12] Br8·9H2O(Fe8) was evaluated in vitro as a new kind of possible MRI contrast agent. Relaxivities were measured at 1.41 and 9.4 T for Fe8 and commercial Gd-DTPA dissolved in PBS. There was significant difference for r1 and r2 values between Fe8 and Gd-DTPA at high field (9.4 T) and for r1 at low field (1.4 T) (p < 0.05). Phantom studies with T1-weighted MRI at 9.4 T suggest T1 contrast potential for Fe8. That is, up to 5.2 times higher intensity enhancement with respect to that of equimolar Gd-DTPA was obtained with an Fe8 concentration, referred to the whole molecule, of 0.2 mM, for which no toxicity on C6 cells could be detected. No toxic effects on cultured C6 cells were observed up to a concentration of 1 mM Fe8. Copyright © 2005 John Wiley & Sons, Ltd.

AB - The complex [(tacn)6Fe8 (μ3-O) 2(μ2 -OH)12] Br8·9H2O(Fe8) was evaluated in vitro as a new kind of possible MRI contrast agent. Relaxivities were measured at 1.41 and 9.4 T for Fe8 and commercial Gd-DTPA dissolved in PBS. There was significant difference for r1 and r2 values between Fe8 and Gd-DTPA at high field (9.4 T) and for r1 at low field (1.4 T) (p < 0.05). Phantom studies with T1-weighted MRI at 9.4 T suggest T1 contrast potential for Fe8. That is, up to 5.2 times higher intensity enhancement with respect to that of equimolar Gd-DTPA was obtained with an Fe8 concentration, referred to the whole molecule, of 0.2 mM, for which no toxicity on C6 cells could be detected. No toxic effects on cultured C6 cells were observed up to a concentration of 1 mM Fe8. Copyright © 2005 John Wiley & Sons, Ltd.

KW - Contrast agent

KW - Fe 8

KW - Magnetic resonance imaging

KW - Molecular magnets

U2 - 10.1002/nbm.959

DO - 10.1002/nbm.959

M3 - Article

SN - 0952-3480

VL - 18

SP - 300

EP - 307

JO - NMR in Biomedicine

JF - NMR in Biomedicine

ER -

In vitro characterization of an Fe<inf>8</inf> cluster as potential MRI contrast agent

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