TY - JOUR
T1 - Impact of laparoscopy to assess resectability in stage IIIC epithelial ovarian, tubal and peritoneal cancer patients
AU - Sánchez-Iglesias, Jose Luis
AU - Perez-Benavente, Assumpció
AU - Correa-Paris, Alejandro
AU - De La Torre Fernandez De Vega, Javier
AU - Carbonell Socias, Melchor
AU - Gil-Moreno, Antonio
PY - 2019/5/1
Y1 - 2019/5/1
N2 - © 2018 S. Karger AG, Basel. All rights reserved. Aims: To evaluate overall survival (OS) and progression-free survival (PFS) in patients with stage IIIC epithelial ovarian, tubal and peritoneal cancer (EOC) who underwent a laparoscopy to assess surgical resectability prior to Primary Debulking Surgery (PDS) or Interval Debulking Surgery (IDS). Methods: Retrospective cohort study that included all women with stage IIIC EOC treated at our center between 2000 and 2010. Patients were classified in groups: PDS, neoadjuvant chemotherapy (NACT) with IDS, NACT without IDS; and then sub-classified based on residual tumor (RT). A laparoscopy to assess resectability was performed before PDS and IDS. Results: Among 111 patients included, 66 underwent PDS, and 45 were treated with NACT, 80% of them receiving subsequent IDS. OS was 75.6 months in the PDS group, and 52.8 months for IDS group (p = 0.100); the PFS was 30 months and 19.2 months respectively (p = 0.049). Median OS was 104.4 and 52.8 months for patients with optimal cytoreduction (RT = 0) in the PDS and IDS group respectively (p < 0.05). Laparoscopy did not modify the preoperative consideration for PDS; however, 9 laparotomies were avoided based on laparoscopic findings after NACT. Conclusion: Laparoscopy for the assessment of surgical resectability in stage IIIC EOC has no impact on survival; but it still could be useful for the reduction of unnecessary laparotomies after NACT.
AB - © 2018 S. Karger AG, Basel. All rights reserved. Aims: To evaluate overall survival (OS) and progression-free survival (PFS) in patients with stage IIIC epithelial ovarian, tubal and peritoneal cancer (EOC) who underwent a laparoscopy to assess surgical resectability prior to Primary Debulking Surgery (PDS) or Interval Debulking Surgery (IDS). Methods: Retrospective cohort study that included all women with stage IIIC EOC treated at our center between 2000 and 2010. Patients were classified in groups: PDS, neoadjuvant chemotherapy (NACT) with IDS, NACT without IDS; and then sub-classified based on residual tumor (RT). A laparoscopy to assess resectability was performed before PDS and IDS. Results: Among 111 patients included, 66 underwent PDS, and 45 were treated with NACT, 80% of them receiving subsequent IDS. OS was 75.6 months in the PDS group, and 52.8 months for IDS group (p = 0.100); the PFS was 30 months and 19.2 months respectively (p = 0.049). Median OS was 104.4 and 52.8 months for patients with optimal cytoreduction (RT = 0) in the PDS and IDS group respectively (p < 0.05). Laparoscopy did not modify the preoperative consideration for PDS; however, 9 laparotomies were avoided based on laparoscopic findings after NACT. Conclusion: Laparoscopy for the assessment of surgical resectability in stage IIIC EOC has no impact on survival; but it still could be useful for the reduction of unnecessary laparotomies after NACT.
KW - Disease-free survival
KW - Laparoscopy
KW - Neoplasm staging
KW - Ovarian epithelial cancer
KW - Overall survival
KW - Peritoneal Neoplasms/pathology
KW - Humans
KW - Middle Aged
KW - Carcinoma, Ovarian Epithelial/pathology
KW - Neoplasm, Residual/pathology
KW - Cytoreduction Surgical Procedures
KW - Neoplasms, Glandular and Epithelial/pathology
KW - Adult
KW - Fallopian Tube Neoplasms/pathology
KW - Female
KW - Neoadjuvant Therapy
KW - Aged
KW - Retrospective Studies
KW - Chemotherapy, Adjuvant
KW - Neoplasm Staging
KW - Cohort Studies
KW - Ovarian Neoplasms/pathology
UR - http://www.mendeley.com/research/impact-laparoscopy-assess-resectability-stage-iiic-epithelial-ovarian-tubal-peritoneal-cancer-patien
U2 - 10.1159/000493794
DO - 10.1159/000493794
M3 - Article
C2 - 30428466
SN - 0378-7346
VL - 84
SP - 259
EP - 267
JO - Gynecologic and Obstetric Investigation
JF - Gynecologic and Obstetric Investigation
ER -