Immunotherapy with fragmented Mycobacterium tuberculosis cells increases the effectiveness of chemotherapy against a chronical infection in a murine model of tuberculosis

Pere Joan Cardona; Isabel Amat; Sergi Gordillo; Virginia Arcos; Evelyn Guirado; Jorge Díaz; Cristina Vilaplana; Gustavo Tapia; Vicenç Ausina

doi:10.1016/j.vaccine.2004.09.008

Immunotherapy with fragmented Mycobacterium tuberculosis cells increases the effectiveness of chemotherapy against a chronical infection in a murine model of tuberculosis

Pere Joan Cardona, Isabel Amat, Sergi Gordillo, Virginia Arcos, Evelyn Guirado, Jorge Díaz, Cristina Vilaplana, Gustavo Tapia, Vicenç Ausina

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

83 Cites (Scopus)

Resum

Reduction of colony forming units by rifampicin-isoniazid therapy given 9-17 weeks post-infection was made more pronounced by immunotherapy with a vaccine made of fragmented Mycobacterium tuberculosis cells detoxified and liposomed (RUTI), given on weeks 17, 19 and 21 post-infection, in the murine model of tuberculosis in C57BL/6 and DBA/2 inbred strains. RUTI triggered a Th1/Th2 response, as demonstrated by the production of IgG1, IgG2a and IgG3 antibodies against a wide range of peptides. The histological analysis did not show neither eosinophilia nor necrosis, and granulomatous infiltration was only slightly increased in C57BL/6 mice when RUTI was administered intranasally. © 2004 Elsevier Ltd. All rights reserved.

Idioma original	Anglès
Pàgines (de-a)	1393-1398
Revista	Vaccine
Volum	23
DOIs	https://doi.org/10.1016/j.vaccine.2004.09.008
Estat de la publicació	Publicada - 3 de febr. 2005

SDG de les Nacions Unides

Aquest resultat contribueix als següents objectius de desenvolupament sostenible.

Accés al document

10.1016/j.vaccine.2004.09.008

Altres arxius i enllaços

https://www.scopus.com/pages/publications/12344310949

Com citar-ho

@article{84fed8f962e44a8d9c1c9833a578f64c,

title = "Immunotherapy with fragmented Mycobacterium tuberculosis cells increases the effectiveness of chemotherapy against a chronical infection in a murine model of tuberculosis",

abstract = "Reduction of colony forming units by rifampicin-isoniazid therapy given 9-17 weeks post-infection was made more pronounced by immunotherapy with a vaccine made of fragmented Mycobacterium tuberculosis cells detoxified and liposomed (RUTI), given on weeks 17, 19 and 21 post-infection, in the murine model of tuberculosis in C57BL/6 and DBA/2 inbred strains. RUTI triggered a Th1/Th2 response, as demonstrated by the production of IgG1, IgG2a and IgG3 antibodies against a wide range of peptides. The histological analysis did not show neither eosinophilia nor necrosis, and granulomatous infiltration was only slightly increased in C57BL/6 mice when RUTI was administered intranasally. {\textcopyright} 2004 Elsevier Ltd. All rights reserved.",

keywords = "Chemotherapy, Histological analysis, Immunotherapy",

author = "Cardona, \{Pere Joan\} and Isabel Amat and Sergi Gordillo and Virginia Arcos and Evelyn Guirado and Jorge D{\'i}az and Cristina Vilaplana and Gustavo Tapia and Vicen{\c c} Ausina",

year = "2005",

month = feb,

day = "3",

doi = "10.1016/j.vaccine.2004.09.008",

language = "English",

volume = "23",

pages = "1393--1398",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier BV",

}

Immunotherapy with fragmented Mycobacterium tuberculosis cells increases the effectiveness of chemotherapy against a chronical infection in a murine model of tuberculosis. / Cardona, Pere Joan; Amat, Isabel; Gordillo, Sergi et al.
In: Vaccine, Vol. 23, 03.02.2005, pàg. 1393-1398.

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

TY - JOUR

T1 - Immunotherapy with fragmented Mycobacterium tuberculosis cells increases the effectiveness of chemotherapy against a chronical infection in a murine model of tuberculosis

AU - Cardona, Pere Joan

AU - Amat, Isabel

AU - Gordillo, Sergi

AU - Arcos, Virginia

AU - Guirado, Evelyn

AU - Díaz, Jorge

AU - Vilaplana, Cristina

AU - Tapia, Gustavo

AU - Ausina, Vicenç

PY - 2005/2/3

Y1 - 2005/2/3

N2 - Reduction of colony forming units by rifampicin-isoniazid therapy given 9-17 weeks post-infection was made more pronounced by immunotherapy with a vaccine made of fragmented Mycobacterium tuberculosis cells detoxified and liposomed (RUTI), given on weeks 17, 19 and 21 post-infection, in the murine model of tuberculosis in C57BL/6 and DBA/2 inbred strains. RUTI triggered a Th1/Th2 response, as demonstrated by the production of IgG1, IgG2a and IgG3 antibodies against a wide range of peptides. The histological analysis did not show neither eosinophilia nor necrosis, and granulomatous infiltration was only slightly increased in C57BL/6 mice when RUTI was administered intranasally. © 2004 Elsevier Ltd. All rights reserved.

AB - Reduction of colony forming units by rifampicin-isoniazid therapy given 9-17 weeks post-infection was made more pronounced by immunotherapy with a vaccine made of fragmented Mycobacterium tuberculosis cells detoxified and liposomed (RUTI), given on weeks 17, 19 and 21 post-infection, in the murine model of tuberculosis in C57BL/6 and DBA/2 inbred strains. RUTI triggered a Th1/Th2 response, as demonstrated by the production of IgG1, IgG2a and IgG3 antibodies against a wide range of peptides. The histological analysis did not show neither eosinophilia nor necrosis, and granulomatous infiltration was only slightly increased in C57BL/6 mice when RUTI was administered intranasally. © 2004 Elsevier Ltd. All rights reserved.

KW - Chemotherapy

KW - Histological analysis

KW - Immunotherapy

UR - https://www.scopus.com/pages/publications/12344310949

U2 - 10.1016/j.vaccine.2004.09.008

DO - 10.1016/j.vaccine.2004.09.008

M3 - Article

SN - 0264-410X

VL - 23

SP - 1393

EP - 1398

JO - Vaccine

JF - Vaccine

ER -

Immunotherapy with fragmented Mycobacterium tuberculosis cells increases the effectiveness of chemotherapy against a chronical infection in a murine model of tuberculosis

Resum

SDG de les Nacions Unides

Accés al document

Altres arxius i enllaços

Fingerprint

Com citar-ho