Resum
Reduction of colony forming units by rifampicin-isoniazid therapy given 9-17 weeks post-infection was made more pronounced by immunotherapy with a vaccine made of fragmented Mycobacterium tuberculosis cells detoxified and liposomed (RUTI), given on weeks 17, 19 and 21 post-infection, in the murine model of tuberculosis in C57BL/6 and DBA/2 inbred strains. RUTI triggered a Th1/Th2 response, as demonstrated by the production of IgG1, IgG2a and IgG3 antibodies against a wide range of peptides. The histological analysis did not show neither eosinophilia nor necrosis, and granulomatous infiltration was only slightly increased in C57BL/6 mice when RUTI was administered intranasally. © 2004 Elsevier Ltd. All rights reserved.
Idioma original | Anglès |
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Pàgines (de-a) | 1393-1398 |
Revista | Vaccine |
Volum | 23 |
DOIs | |
Estat de la publicació | Publicada - 3 de febr. 2005 |