Immunohistochemical expression profile and prognosis in patients with diffuse large B-cell lymphoma with or without human immunodeficiency virus infection

Blanca Xicoy, Josep Maria Ribera*, José Lus Mate, Gustavo Tapia, Mireia Morgades, José Tomas Navarro, Carolina Sanz, Aurelio Ariza, Evarist Feliu

*Autor corresponent d’aquest treball

Producció científica: Contribució a revistaArticleRecercaAvaluat per experts

14 Cites (Scopus)

Resum

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype in non-immunosuppressed and in human immunodeficiency virus (HIV)-positive patients. The prognosis of DLBCL with germinal center (GC) phenotype is better than that of the non-germinal center (non-GC) phenotype by immunohistochemical expression profile (IHC) in some studies but not in others. The frequency and the prognosis of these phenotypic subtypes in DLBCL related to HIV infection is not well known. The objectives of this study were to characterize the IHC by tissue microarray in 98 patients with DLBCL, 34 of whom were HIV-positive, and to evaluate their prognosis. Patients with HIV-related DLBCL with a non-GC pattern had poorer prognosis than patients with non-HIV-related DLBCL with the same pattern, but this difference disappeared when we considered only patients receiving HAART.

Idioma originalAnglès nord-americà
Pàgines (de-a)2063-2069
Nombre de pàgines7
RevistaLeukemia and Lymphoma
Volum51
Número11
DOIs
Estat de la publicacióPublicada - de nov. 2010

Fingerprint

Navegar pels temes de recerca de 'Immunohistochemical expression profile and prognosis in patients with diffuse large B-cell lymphoma with or without human immunodeficiency virus infection'. Junts formen un fingerprint únic.

Com citar-ho