TY - JOUR
T1 - Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients
AU - Gutiérrez Casbas, Ana
AU - Zapater, Pedro
AU - Ricart, Elena
AU - González-Vivó, María
AU - Gordillo, Jordi
AU - Olivares, David
AU - Vera, Isabel
AU - Mañosa i Ciria, Míriam
AU - P. Gisbert, Javier
AU - Aguas, Mariam
AU - Sánchez-Rodríguez, Eugenia
AU - Bosca-Watts, Maia
AU - Laredo, Viviana
AU - Camps, Blau
AU - Marín-Jiménez, Ignacio
AU - Zabana, Yamile
AU - Martín-Arranz, María Dolores
AU - Muñoz, Roser
AU - Navarro, Mercè
AU - Sierra, Eva
AU - Madero, Lucía
AU - Vela, Milagros
AU - Pérez-Calle, José Lázaro
AU - Sainz, Empar
AU - Calvet Calvo, Xavier
AU - Arias García, Lara
AU - Morales, Victor
AU - Bermejo, Fernando
AU - Fernández-Salazar, Luis
AU - Van Domselaar, Manuel
AU - De Castro, Luisa
AU - Rodríguez, Cristina
AU - Muñoz-Villafranca, Carmen
AU - Lorente, Rufo
AU - Rivero, Montserrat
AU - Iglesias, Eva
AU - Herreros Martínez, Belén
AU - Busquets, David
AU - Riera, Joan
AU - Martínez-Montiel, María Pilar
AU - Roldón, Marta
AU - Roncero, Oscar
AU - Hinojosa, Esther
AU - Sierra Ausín, Mónica
AU - Barrio, Jesús
AU - de Francisco, Ruth
AU - Huguet, José María
AU - Merino, Olga
AU - Carpio, Daniel
AU - Ginard, Daniel
AU - Muñoz, Fernando
AU - Piqueras, Marta
AU - Almela, Pedro
AU - Argüelles-Arias, Federico
AU - Alcaín, Guillermo
AU - Bujanda, Luis
AU - Manceñido, Noemí
AU - Lucendo, Alfredo J.
AU - Varela, Pilar
AU - Rodríguez-Lago, Iago
AU - Ramos López, Laura
AU - Sempere, Laura
AU - Sesé, Eva
AU - Barreiro de-Acosta, Manuel
AU - Domènech, Eugeni
AU - Francés, Rubén
PY - 2022
Y1 - 2022
N2 - Previous studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. Prospective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. We included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, p < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, p < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92-2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0-1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. Compared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe.
AB - Previous studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. Prospective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. We included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, p < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, p < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92-2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0-1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. Compared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe.
KW - Immigrant
KW - Phenotype
KW - Biologics
KW - Inflammatory bowel disease
KW - Crohn's disease
KW - Ulcerative colitis
U2 - 10.3389/fmed.2022.823900
DO - 10.3389/fmed.2022.823900
M3 - Article
C2 - 35178413
SN - 2296-858X
VL - 9
JO - Frontiers in Medicine
JF - Frontiers in Medicine
ER -