Imaging of cellular aging in human retinal blood vessels

Joana Catita; Mariana Lopez Luppo; David Ramos Gonzalez; Victor Nacher Garcia; Marc Navarro Beltran; Ana Maria Carretero Romay; A Sánchez-Chardi; Prof. Luísa Mendes-Jorge; Alfonso Rodriguez Baeza; Jesus Ruberte Paris

doi:10.1016/j.exer.2015.03.019

Imaging of cellular aging in human retinal blood vessels

Joana Catita, Mariana Lopez Luppo, David Ramos Gonzalez, Victor Nacher Garcia, Marc Navarro Beltran, Ana Maria Carretero Romay, A Sánchez-Chardi, Prof. Luísa Mendes-Jorge, Alfonso Rodriguez Baeza, Jesus Ruberte Paris^*

^*Autor corresponent d’aquest treball

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© 2015 Elsevier Ltd. To date two main aging vascular lesions have been reported in elderly human retinas: acellular capillaries and microaneurysms. However, their exact mechanism of formation remains unclear. Using high resolution microscopy techniques we revise cellular alterations observed in aged human retinal vessels, such as lipofuscin accumulation, caveolae malfunction, blood basement membrane disruption and enhanced apoptosis that could trigger the development of these aging vascular lesions. Moreover, we have generated a set of original images comparing retinal vasculature between middle and old aged healthy humans to show in a comprehensive manner the main structural and ultrastructural alterations occurred during age in retinal blood vessels.

Idioma original	Anglès
Pàgines (de-a)	14-25
Revista	Experimental Eye Research
DOIs	https://doi.org/10.1016/j.exer.2015.03.019
Estat de la publicació	Publicada - 1 de juny 2015

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@article{a75aef22d4c5477f9054763a610f532b,

title = "Imaging of cellular aging in human retinal blood vessels",

abstract = "{\textcopyright} 2015 Elsevier Ltd. To date two main aging vascular lesions have been reported in elderly human retinas: acellular capillaries and microaneurysms. However, their exact mechanism of formation remains unclear. Using high resolution microscopy techniques we revise cellular alterations observed in aged human retinal vessels, such as lipofuscin accumulation, caveolae malfunction, blood basement membrane disruption and enhanced apoptosis that could trigger the development of these aging vascular lesions. Moreover, we have generated a set of original images comparing retinal vasculature between middle and old aged healthy humans to show in a comprehensive manner the main structural and ultrastructural alterations occurred during age in retinal blood vessels.",

keywords = "Acellular capillaries, Aging, Cellular senescence, Lipofuscin accumulation, Microaneurysms",

author = "Joana Catita and \{Lopez Luppo\}, Mariana and \{Ramos Gonzalez\}, David and \{Nacher Garcia\}, Victor and \{Navarro Beltran\}, Marc and \{Carretero Romay\}, \{Ana Maria\} and A S{\'a}nchez-Chardi and \{Prof. Lu{\'i}sa Mendes-Jorge\} and \{Rodriguez Baeza\}, Alfonso and \{Ruberte Paris\}, Jesus",

year = "2015",

month = jun,

day = "1",

doi = "10.1016/j.exer.2015.03.019",

language = "English",

pages = "14--25",

}

TY - JOUR

T1 - Imaging of cellular aging in human retinal blood vessels

AU - Catita, Joana

AU - Lopez Luppo, Mariana

AU - Ramos Gonzalez, David

AU - Nacher Garcia, Victor

AU - Navarro Beltran, Marc

AU - Carretero Romay, Ana Maria

AU - Sánchez-Chardi, A

AU - Prof. Luísa Mendes-Jorge,

AU - Rodriguez Baeza, Alfonso

AU - Ruberte Paris, Jesus

PY - 2015/6/1

Y1 - 2015/6/1

N2 - © 2015 Elsevier Ltd. To date two main aging vascular lesions have been reported in elderly human retinas: acellular capillaries and microaneurysms. However, their exact mechanism of formation remains unclear. Using high resolution microscopy techniques we revise cellular alterations observed in aged human retinal vessels, such as lipofuscin accumulation, caveolae malfunction, blood basement membrane disruption and enhanced apoptosis that could trigger the development of these aging vascular lesions. Moreover, we have generated a set of original images comparing retinal vasculature between middle and old aged healthy humans to show in a comprehensive manner the main structural and ultrastructural alterations occurred during age in retinal blood vessels.

AB - © 2015 Elsevier Ltd. To date two main aging vascular lesions have been reported in elderly human retinas: acellular capillaries and microaneurysms. However, their exact mechanism of formation remains unclear. Using high resolution microscopy techniques we revise cellular alterations observed in aged human retinal vessels, such as lipofuscin accumulation, caveolae malfunction, blood basement membrane disruption and enhanced apoptosis that could trigger the development of these aging vascular lesions. Moreover, we have generated a set of original images comparing retinal vasculature between middle and old aged healthy humans to show in a comprehensive manner the main structural and ultrastructural alterations occurred during age in retinal blood vessels.

KW - Acellular capillaries

KW - Aging

KW - Cellular senescence

KW - Lipofuscin accumulation

KW - Microaneurysms

UR - https://www.scopus.com/pages/publications/84927725723

U2 - 10.1016/j.exer.2015.03.019

DO - 10.1016/j.exer.2015.03.019

M3 - Review article

SN - 0014-4835

SP - 14

EP - 25

JO - Experimental Eye Research

JF - Experimental Eye Research

ER -

Imaging of cellular aging in human retinal blood vessels

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